Antigenicity and gene characterization of hemagglutinin genes in Victoria lineage of influenza B virus prevalent in Xinjiang from 2021-2022

Abstract

Abstract: Objective To analyze the antigenicity and genetic characteristics of the hemagglutinin（HA） gene in the Victoria lineage of the influenza B virus（BV） prevalent in Xinjiang from 2021-2022. Methods A total of 30 BV strains isolated from 15 influenza surveillance network laboratories in Xinjiang were randomly selected for antigenicity analysis using BV vaccine strain B/Washington/02/2019（2021-2022） recommended by World Health Organization（WHO） as reference,and the whole genome of the above strains was sequenced. The HA gene evolution was analyzed by MEGA X and BioEdit software. Results Compared with vaccine strains,20.00%（6/30） influenza strains were similar strains,and 80.00%（24/30） were low response strains. The HA gene of the 30 influenza strains was closely related to the vaccine strains in terms of evolution,and was characterized by three-deletion sequence 162-164. Compared with vaccine strains,the nucleotide and amino acid homologies were 93.0%-98.9% and 94.0%-98.3%,respectively. There were 10 amino acid mutations in the HA gene of 30 influenza strains and vaccine strains：D129K,R133G,E136R,E198K,A202K,K56T,T73V,Y179H,E183K,and N233D. Conclusions Most of the influenza B strains prevalent in Xinjiang in 2021-2022 are closely related to the vaccine strain on the HA gene,but the vaccine protection effect may be poor due to multiple mutations at the HA amino acid sites. Therefore,it is necessary to carry out antigenicity analysis and gene monitoring of BV strain.

Key words: influenza B virus, Antigenicity, Gene characterization

CLC Number:

R373.1⁺3

CHEN Yuan, ZHANG Xuan, ZHAO Jun, Nigedeli·Alitengsaier, LI Quan-xi, MA Xin. Antigenicity and gene characterization of hemagglutinin genes in Victoria lineage of influenza B virus prevalent in Xinjiang from 2021-2022. [J]OCCUPATION AND HEALTH, 2023, 39(11): 1473-1478.

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