Objective To explore the influence and mechanism of mobile phone addiction， interaction anxiousness and alexithymia on life satisfaction. Methods A total of 1 028 freshmen in a medical college in Shandong Province were investigated with the Mobile Phone Addiction Tendency Scale（MPATS）， Interaction Anxiety Scale（IAS）， Toronto Alexithymia Scale（TAS） and Adolescent Student’s Life Satisfaction Scale（ASLSS） in September 2018. Results Mobile phone addiction was positively correlated with interaction anxiousness and alexithymia （r=0.325， 0.546， both P<0.01）， and negatively correlated with life satisfaction （r=-0.278， P<0.01）. Bootstrap mediating effect test showed that the mediating effect value of IAS score between MPATS score

and life satisfaction was -0.052， accounting for 18.71% of the total effect， the mediating effect value of TAS score between MPATS score and life satisfaction was -0.180， accounting for 64.75% of the total effect， and the value of chain mediated effect nof IAS and TAS score between cell phone addiction and life satisfaction was -0.035， accounting for 12.59% of the total effect. Conclusion Interaction anxiousness and alexithymia of freshmen completely mediate the influence of mobile phone addiction on life satisfaction

Mobile phone addiction, Interaction anxiousness, Alexithymia, Life satisfaction