Abstract: Objective To evaluate of radiation protection effect of new nuclear medicine department in a hospital of Danzhou City，understand the radiation protection level of single-photon emission computed tomography（SPECT-CT），thyroid function determination and hyperthyroidism therapy. Methods From August to October 2021，the field investigation and testing method were used to conduct the radiation protection detection，surface pollution detection，equipment performance detection，ventilation detection and radiation protection evaluation in the workplace of new nuclear medicine department in a hospital of Danzhou City. Results The dose rates of injection table window（open），cabinet observation window，operation port（open），waste room protection door，observation room protection door in SPECT-CT work area were high. The peripheral dose equivalent rate of computed tomography（CT） workplace radiation level in SPECT-CT was 0.13-0.19 μSv/h，which was in the environmental base level. The surface contamination detection results in radiation workplace of nuclear medicine department were less than the low limit of detection，that was <0.09 Bq/cm². The equipment performance detection indicators of SPECT and CT in SPECT-CT all met the relevant standards. The wind speed of ventilation cabinet section did not reach 1 m/s，and ventilation in some radioactive workplaces was less than 4 times/h. Conclusions It is suggested that the hospital should strengthen the radiation protection management for the areas with high dose rate，set up warning signs and warning instructions in Chinese，and the medical staff and the interviewees stay briefly，and shall not stay in the above areas after the completion of the prescribed process. It is necessary to use the high-power fan in the ventilation cabinet to increase the cross-section wind speed. The one-way electric valve should be added in functional rooms to avoid ventilation exchange of ventilation pipes between rooms. It is necessary feasible to add the replaceable activated carbon filter device at the exhaust outlet of the ventilation cabinet and functional rooms，and replace the activated carbon regularly.

Key words: Nuclear medicine department, Single-photon emission computed tomography, Hyperthyroidism therapy, Radiation protection