Abstract: Objective To analyze the epidemiological characteristics and the disease burden of other infectious diarrhea in Yantian District of Shenzhen City from 2010 to 2022,and provide evidence for formulating effective prevention and control measures. Methods Descriptive analysis was used to describe epidemiological characteristics of other infectious diarrhea reported by China's Disease Control and Prevention Information System.Space-time aggregation detection on the community scale was conducted,a joinpoint regression model was used to analyze the change trend of morbidity,and the epidemiological burden of disease was estimated by years of years lived with disability（YLDs）. Results The average annual incidence of other infectious diarrhea in Yantian District of Shenzhen City from 2010 to 2022 was 203.99/100 000,and the average annual incidence rate（156.10/100 000） from 2020 to 2022 was lower than that of 2010 to 2019（218.33/100 000）,and the difference was statistically significant（P<0.01）. The ratio of incidence rate between men and women was 1.36∶1,The highest incidence was in the 0-<5 year old group（2 445.22/100 000）,and cases were mainly scattered children（63.85%）. The onset time showed a certain seasonality,with two peaks in winter and summer. Rotavirus infection was the main cause in 80.27% of the population.The community with high incidence was the area behind Yantian Port（LLR=99.01,RR=5.64,P<0.01）. The results of Joinpoint regression analysis showed that the overall reported incidence rate from 2010 to 2022 showed a downward trend,but the difference was not statistically significant（AAPC=-3.83%,P>0.05）,and the incidence rate of the 0-1 year old group from 2010 to 2022 showed a significant decline and the difference was statistically significant（APC=-6.89%,P<0.05）.Disability-adjusted life year（DALY） attributed to infectious diarrhea was 19.10 years,and the burden of disease was the greatest in the 0-<5 year old group（7.66 years）. Conclusion From 2010 to 2022,other infectious diarrhea remained an epidemic in Yantian District of Shenzhen City,and comprehensive control and prevention measures needed to be carried out for different characteristic populations and high-risk communities.

Key words: Other infectious diarrhea, Epidemic characteristics, Burden of disease, Etiological surveillance