Abstract: Objective To investigate the effects of combined noise and dust on ECG and blood pressure in calcium carbonate processing workers. Methods From January to June 2022,907 workers in the calcium carbonate processing industry exposed to dust or noise and 482 administrators without dust or noise exposure in Hezhou City were selected as the study subjects. The physical examination information of the subjects was collect and the impact of noise combined with dust on ECG and blood pressure of workers in calcium carbonate processing industry was analyzed. Results The incidence of abnormal ECG and abnormal blood pressure of related personnel in calcium carbonate processing industry（12.97% and 20.84%） was greatly higher than that of administrative personnel without dust and noise exposure（5.60% and 11.20%）（both P<0.05）.The results of single factor analysis showed that the occurrence of abnormal ECG and abnormal blood pressure of relevant personnel in calcium carbonate processing industry were affected by gender,age,body mass index,working years and occupational exposure types of practitioners（all P<0.05）.In addition,abnormal blood pressure was also affected by smoking and drinking among staff（P<0.05）.The results of multivariate logistic regression analysis showed that compared with the workers in calcium carbonate processing industry exposed to dust alone,the workers exposed to noise and dust had a higher risk of abnormal ECG（OR=4.728,95%CI：1.857-12.102） and higher risk of abnormal blood pressure（OR=5.076,95%CI：3.348-7.695）. Conclusion Both the simple dust effect and the combined effect of noise and dust will affect the ECG and blood pressure related to calcium carbonate processing industry,and the combined effect of noise and dust is more significant.

Key words: Noise, Dust, Calcium carbonate processing, Electrocardiogram, Blood pressure