Abstract: Objective To establish an occupational health detection method for simultaneous determination of 16 metals and their soluble compounds in microporous filter membranes,including cadmium,chromium,manganese,zinc,copper,iron,calcium,magnesium,cesium,indium,strontium,bismuth,germanium,tantalum,zirconium and tin. Methods A microporous filter membrane was used to collect 16 metals and their soluble compounds in the workplace air,and the nitric acid solution was digested and transferred to the colorimetric tube to determine the volume,and the mass concentration of 16 metals and their soluble compounds was determined by inductively coupled plasma-mass spectrometry（ICP-MS）. Results The linear relationship between the 16 metal elements in the range of 0.00-1 000.00 μg/L was good,with a correlation coefficient of 0.999 7-1.000 0,the detection limit was 0.10-3.11 μg/L,and the lower limit of quantification was 0.33-10.36 μg/L. The minimum detection concentration was 0.01×10^-3-0.41×10^-3 mg/m³,and the minimum quantitative concentration was 0.06×10^-3-1.38×10^-3 mg/m³（calculated by collecting 75 L air samples on site）. The recovery rate of spiked was 96.41%-104.18%,and the relative standard deviation was 0.14%-3.14%. The samples could be stably stored at room temperature for at least 7 days before digestion and determination. Conclusion This method can optimize the procedure and improve the work efficiency,and conforms to the development specifications of the determination method of chemical substances in workplace air,and can be used for the simultaneous determination of 16 metals and their soluble compounds in workplace air,including cadmium,chromium,manganese,zinc,copper,iron,calcium,magnesium,cesium,indium,strontium,bismuth,germanium,tantalum,zirconium and tin.

Key words: Metals and their soluble compounds, Inductively coupled plasma mass spectrometry, Simultaneous determination method