Analysis on clinical value of combined detection of urine β2-MG and γ-GT in diagnosis of renal injury in patients with occupational lead poisoning

Abstract

Abstract: Objective To explore the clinical value of combined detection of urineβ 2-microglobulin（β2-MG） and γ-glutamyl transferase（γ-GT） in the diagnosis of renal injury in patients with occupational lead poisoning. Methods A total of 98 occupational lead poisoning patientsadmitted to the Jingmen Second People's Hospital from January 2020 to January 2022 were selected as the observation group. Meanwhile,72 individuals with occupational lead exposure but with normal blood lead level were selected as the control group,and 67 individuals without lead exposure history and with normal blood lead level were selected as the healthy group. The levels of blood lead and zinc protoporphyrin（ZPP） in the three groups of subjects were detected. The blood and urine samples were collected to detect the levels of serum uric acid（UA）,creatinine（Cr） and blood urea nitrogen（BUN）,urine β2-MG and γ-GT. The 24h urinary albumin excretion rate（UAER） of 30mg/24h was taken as the golden standard for kidney injury to analyze the performance of β2-MG,γ-GT alone and in combination to diagnose renal injury in patients with occupational lead poisoning using the receiver operating characteristic（ROC） curve. Results The blood lead levelin the observation group,the control group and the healthy group was （631.37±113.85）,（70.13±19.62） and （22.59±5.21）μg/L,respectively. The ZPP level was（3.12±0.36）,（2.85±0.29） and （2.51±0.27）μmol/L,respectively. All differences were statistically significant（all P<0.05）. There were no statistically significant differences levels of blood UA,Cr and BUN among the three groups（all P>0.05）. The urine β2-MG level in the observation group,the control group and the healthy group was（0.93±0.30）,（0.17±0.04） and （0.13±0.02）mg/L,respectively. The γ-GT level was （91.35±10.62）,（32.28±8.15） and （26.13±5.24）U/L,respectively. All differenceswere statistically significant（all P<0.05）. The ROC curve analysis showed that the sensitivity,specificity and area under the curve of urine β2-MG combined with γ-GT to diagnose kidney injury in occupational lead poisoning was 95.90%,94.40% and 0.952,respectively,which were significantly higher than those of alone detection of the two,and the differences were statistically significant（all P<0.05）. Conclusion The combined detection of urine β2-MG andγ-GT can be used as important indicators of renal injury in patients with occupational lead poisoning,with high diagnostic value in clinical practice.

Key words: Lead poisoning, Renal injury, β2-microglobulin, γ-glutamyltransferase

CLC Number:

R135.1⁺1

ZENG Xiao-yun, CHEN Wei-yang. Analysis on clinical value of combined detection of urine β2-MG and γ-GT in diagnosis of renal injury in patients with occupational lead poisoning. [J]OCCUPATION AND HEALTH, 2023, 39(12): 1604-1607.

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