Abstract: Objective To follow up and analyze the results of neuro electromyography（EMG） in patients with occupational chronic n-hexane poisoning,and to analyze the general clinical indicators and related nutritional status of patients,and to explore the impact of nutritional status on disease recovery. Methods A retrospective analysis was conducted on 62 patients with occupational chronic n-hexane poisoning admitted from 2008 to 2021,and they were selected as the case group. Totally 62 healthy examiners during the same period were selected as the control group,and the clinical data and electromyography results of the two groups were compared. Follow up and compare the electromyographic examination results of each patient in the case group before treatment and 3 and 6 months after treatment. Grouping within the case group,patients diagnosed with mild poisoning were divided into one group（mild group）,and patients diagnosed with moderate to severe poisoning were divided into another group（moderate to severe group）. The nutritional status of the two groups,such as body mass index（BMI）,hemoglobin,total cholesterol,triglycerides, blood glucose,and serum albumin were compared. Results The motor nerve latency in the case group was delayed than in the controls（all P<0.05）,and the motor nerve conduction velocity（MCV） and sensory nerve conduction velocity（SCV） of the case group were all slowed down compared to the control group（both P<0.05）. In the case group,the proximal latency of the ulnar nerve[6.95（6.38,7.98）ms] was shortened after 3 months of treatment（P<0.05）,while the rest of the nerve latency did not improve significantly. In MCV,the conduction velocity of the ulnar nerve[53.80（46.34,57.95）m/s] increased（P<0.05）,while the improvement in conduction velocity of the median nerve and common peroneal nerve was not significant. In SCV,the conduction velocity of the ulnar nerve[43.08（38.83,47.79）m/s] increased（P<0.018）,while the improvement in the conduction velocity of the median nerve was not significant. Six months after treatment,the distal latency of the median nerve[3.36（2.89,3.82）ms],the proximal latency of the median nerve[7.28（6.54,8.35）ms],the distal latency of the ulnar nerve[2.60（2.39,3.06）ms],and the proximal latency of the ulnar nerve[6.78（6.29,7.81）ms] were all shortened compared to admission（all P<0.018）,while the improvement in the distal and proximal latency of the common peroneal nerve was not significant. MCV and SCV were significantly accelerated（all P<0.018）. In the case group,the hemoglobin[（135.85±10.87）g/L],red blood cells[（4.52±0.55）×10¹²/L] and serum albumin[（44.51±4.65）g] in the mild group were significantly higher than those in the moderate to severe group（all P<0.05）. Multivariate logistic regression analysis showed that,hemoglobin（OR=0.99,95%CI：0.93-1.05）、red blood cells（OR=0.21,95%CI：0.03-1.47）,serum albumin（OR=0.78, 95%CI：0.64-0.95） were protective factors for moderate to severe poisoning,while fasting blood glucose（OR=18.42,95%CI：2.14-159.01） was a risk factor for moderate to severe poisoning. Conclusion The neuroelectromyographic examination results of patients with n-hexane poisoning did not show significant improvement after 3 months of treatment,but showed significant improvement after 6 months of treatment. Early improvement of the patient's nutritional status can accelerate the recovery of peripheral nerve function in patients with n-hexane poisoning.

Key words: N-hexane poisoning, Neuroelectromyography, Nutritional status