Abstract: Objective To systematically evaluate the prevalence and risk factors of pneumoconiosis complicated with chronic obstructive pulmonary disease（COPD）. Methods The literature related to the prevalence and risk factors of pneumoconiosis complicated with COPD was searched in PubMed,Cochrane Library,Web of Sciencee（WOS）,CBM,CNKI,Wanfang Database from the establishment of the library to July 2022. Two researchers screened the literature,extracted valid data and evaluated the quality of the included studies independently. Meta-analysis was carried out using STATA 16.0. Results A total of 25 studies,including 10 882 participants and 4 141 patients with pneumoconiosis complicated with COPD were included.The meta-analysis showed that the prevalence of pneumoconiosis complicated with COPD was 41.36%,95%CI was 33.41%-49.31%. The age（OR=1.83,95%CI=1.28-2.60）,dust-exposure duration（OR=1.97,95%CI=1.12-3.45）,pneumoconiosis stage（OR=2.64,95%CI=2.16-3.23）,smoking history（OR=1.92,95%CI=1.65-2.23）,smoking index（OR=1.98,95%CI=2.12-3.49）,living environment（OR=2.55,95%CI=1.64-3.97）,education level（OR=1.42,95%CI=1.04-1.93） and family history of respiratory diseases（OR=2.63,95%CI=1.78-3.89） were risk factors for pneumoconiosis complicated with COPD. The body mass index（OR=1.63,95%CI=0.86-3.11） was not statistically correlated with pneumoconiosis patients complicated with COPD. Conclusions The prevalence of pneumoconiosis complicated with COPD is high. Age,dust-exposure duration,pneumoconiosis stage,smoking history,smoking index,messy living environment,lower education level,and family history of respiratory diseases are risk factors for pneumoconiosis with COPD,among which the risk factor of pneumoconiosis stage is the strongest association with the occurrence of pneumoconiosis complicated with COPD. Identifying many risk factors is of great help to prevent the occurrence of pneumoconiosis complicated with COPD.

Key words: Pneumoconiosis, Chronic obstructive pulmonary disease, Prevalence, Risk factors, Meta-analysis