Prevalence of nonalcoholic fatty liver disease in Chinese adults：A meta-analysis

Abstract

Abstract: Objective To systematically evaluate the prevalence of nonalcoholic fatty liver disease（NAFLD） among Chinese adults. Methods The studies on NAFLD in Chinese adults were searched in databases of CNKI,WanFang Data,VIP,CBM,PubMed,Web of Science,the Cochrane Library,and Embase,from inception to March 31,2022. Two researchers performed literature screening and data extraction,and assessed the quality of these studies. Meta-analysis was performed by using Stata 15.0 software. Results Totally 60 studies were included,involving 354 335 cases.The overall prevalence of NAFLD in Chinese adults was 25.5%（95%CI：22.8%-28.2%）. The subgroup analysis showed that the prevalence of NAFLD increased over time. The prevalence of men was higher than that of women. The prevalence of men increased significantly in 29-<39 years old group,and reached a peak at 39-<49 years old group. The prevalence of women increased significantly 49-<59 years old group,and reached a peak at 59-<69 years old group. The higher the body mass index,the higher the prevalence. The prevalence in the northern region was higher than that in the southern region. Conclusions The prevalence of NAFLD in Chinese adults is high,with differences in prevalence by gender,age, body mass index and region. The national health department should develop a precise prevention and control strategy to curb the prevalence of NAFLD in China.

Key words: Nonalcoholic fatty liver disease, Adults, Prevalence, Meta-analysis

CLC Number:

R181.2

LIAO Jiaqian, WANG Guorong, YANG Jing, ZHANG Tian, DENG Xiaoyuan, LIU Yao. Prevalence of nonalcoholic fatty liver disease in Chinese adults：A meta-analysis. [J]OCCUPATION AND HEALTH, 2023, 39(16): 2276-2281.

References

[1] POWELL E E,WONG V W,RINELLA M.Non-alcoholic fatty liver disease[J].Lancet,2021,397(10290):2212-2224.
[2] YOUNOSSI Z M,KOENIG A B,ABDELATIF D,et al.Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence,incidence,and outcomes[J].Hepatology,2016,64(1):73-84.
[3] 肖倩倩,王梦雨,范建高.亚太肝病研究学会代谢相关脂肪性肝病临床诊疗指南(治疗部分)简介[J].临床肝胆病杂志,2021,37(1):41-45.
[4] FAN J G,KIM S U,WONG V W.New trends on obesity and NAFLD in Asia[J].J Hepatol,2017,67(4):862-873.
[5] 范建高,曾静.非酒精性脂肪性肝病的流行现状与危害[J].中华消化杂志,2020,40(9):577-580.
[6] 曾宪涛,刘慧,陈曦,等.Meta分析系列之四:观察性研究的质量评价工具[J].中国循证心血管医学杂志,2012,4(4):297-299.
[7] 刘亚,任伟,郁秋荣,等.1 021例女性医务人员代谢综合征和非酒精性脂肪肝的患病率及两者之间关系的调查分析[J].医学综述,2020, 26(16):3298-3302.
[8] 尚红光,卫俊峰,陈秋生,等.2015年河北省某国有煤矿企业职工非酒精性脂肪肝的流行病学调查[J].职业与健康,2018,34(2):196-199,203.
[9] 王小瑞,王晓荣,陈晓聿,等.包头市非酒精性脂肪肝及代谢综合征现状调查分析[J].疾病监测与控制,2016,10(10):819-821.
[10] 刘英,杨立强.北京某高校教职工非酒精性脂肪性肝病的患病率及相关疾病分析[J].中国医药导报,2017,14(32):178-181.
[11] 孙辉,王佑娟,曾莉,等.成都地区非酒精性脂肪肝患病率及危险因素分析[J].现代预防医学,2009,36(1):6-8.
[12] 秦恳,周婷,吴琴琴,等.成都地区非酒精性脂肪肝与代谢综合征相关性研究[J].现代预防医学,2012,39(10):2395-2397.
[13] 杨兴祥,刘玉萍,戴敏,等.成都市健康体检成人非酒精性脂肪肝流行病学研究[J].中华健康管理学杂志,2010,4(1):22-24.
[14] 周卫东,车志宏,杨亚玲,等.成人非酒精性脂肪肝与代谢综合征关系的研究[J].中国实用内科杂志,2008,28(8):641-643.
[15] 陈刚,冯卫国,毛建军,等.非肥胖老年人血清尿酸水平与非酒精性脂肪性肝病的关系研究[J].浙江医学,2018,40(18):2048-2050.
[16] 王凌,沈振海,徐勤,等.非酒精性脂肪肝的患病率及与代谢综合征关系的研究[J].中国疗养医学,2010,19(5):467-470.
[17] 何粤发,陈波波,杨光.非酒精性脂肪肝的社区调查[J].中华临床医师杂志(电子版),2012,6(15):4446-4448.
[18] 鄢萍,黄中清,王丽宁,等.非酒精性脂肪肝与动脉粥样硬化危险因素相关性调查[J].中国医药导报,2013,10(6):158-159,162.
[19] 陈雪梅,邵虹,周佩明,等.佛山市律师非酒精性脂肪肝患病率调查[J].现代临床医学生物工程学杂志,2005,11(2):132-133.
[20] 梁乐乐,陈金华,亢秀丽,等.高校教师非酒精性脂肪性肝病的流行病学调查及危险因素分析[J].当代医药论丛,2022,20(1):94-98.
[21] 周永健,聂玉强,李瑜元,等.广东省成人代谢综合征与非酒精性脂肪肝患病的关系[J].胃肠病学和肝病学杂志,2008,17(8):647-649.
[22] 甘小玲,陈庆瑜,陈锦武,等.广州老年人非酒精性脂肪肝的流行情况及其与代谢综合征的关系[J].国际医药卫生导报,2015,21(23):3432-3434.
[23] 林妙霞,罗敏琪,余超,等.广州市成人非酒精性脂肪性肝病患病分析[J].中国公共卫生,2010,26(11):1418-1419.
[24] 曹意,王澄,师雯琦,等.广州市中老年人非酒精性脂肪肝患病率及代谢相关因素分析[J].中华流行病学杂志,2015,36(9):958-961.
[25] 叶瑶,于健,汪琳姣,等.桂林市6 660名体检人群非酒精性脂肪肝与代谢综合征的相关性分析[J].基础医学与临床,2014,34(4):509-513.
[26] 陈俭静,芦建慧,彭相文,等.哈尔滨市机关职员非酒精性脂肪性肝病流行病学调查[J].中华疾病控制杂志,2012,16(11):933-936.
[27] 阮建文,高丽娟,梁雄飞,等.海口地区体检人群非酒精性脂肪性肝病患病率调查分析[J].临床肝胆病杂志,2018,34(9):1925-1928.
[28] 赵晓云,陈伟华,路永刚,等.河北省33 843机关职员非酒精性脂肪肝患病率及其危险因素[J].中国老年学杂志,2013,33(20):5079-5081.
[29] 欧阳琴,王志音,马臻.湖北某大学职工非酒精性脂肪性肝病流行病学调查及中西医结合治疗临床观察[J].中西医结合肝病杂志,2019, 29(6):510-512,519.
[30] 王林,夏春玲,范玲.护理人员睡眠状况与非酒精性脂肪性肝病的关系[J].环境与职业医学,2020,37(5):497-502.
[31] 常嘉琪,严威.吉林市非酒精性脂肪性肝病流行病学调查与分析[J].中外妇儿健康,2011,19(9):352-353.
[32] 谭君劲,望长记,冯觉锐,等.江门市荷塘镇非酒精性脂肪肝(NAFLD)的患病率及相关因素分析[J].现代医院,2015,15(7):147-148,151.
[33] 王俊涛. 金华地区健康体检人群非酒精性脂肪肝患病率及代谢相关危险因素调查分析[J].中国农村卫生事业管理,2016,36(11):1481-1484.
[34] 刘丽娟,郭晓颖,张忠平,等.兰州市中老年人非酒精性脂肪性肝病患病情况[J].中国公共卫生,2014,30(6):701-704.
[35] 陈蒙,杨雪,朱守林.连云港市社区居民非酒精性脂肪性肝病流行现状及影响因素[J].华南预防医学,2021,47(7):913-916.
[36] 吴华敏. 某高校教职工非酒精性脂肪性肝病与血脂异常、高尿酸、高血糖的相关性分析及社区干预[J].中国社区医师,2019,35(26):176-177,179.
[37] 孙慧文,占伊扬,陈敏敏,等.南京地区事业单位老年人群非酒精性脂肪肝相关代谢指标分析[J].中华全科医学,2021,19(6):1035-1038.
[38] 张红燕,龚毅红,倪雪君,等.南通市体检人群中非酒精性脂肪肝患病情况及危险因素探讨[J].中国现代医生,2012,50(34):23-26.
[39] 袁芳,王立群,王志忠.宁夏55岁及以上社区体检人群非酒精性脂肪性肝炎的影响因素分析[J].世界最新医学信息文摘,2019,19(20):252-253,257.
[40] 路青玲,王婷,张海东,等.宁夏泾源县非酒精性脂肪性肝病的患病率及其危险因素调查[J].中华健康管理学杂志,2018,12(3):237-242.
[41] 王宏伟,曹丽丽,胡寒冰,等.平顶山市矿区非酒精性脂肪肝的患病率及危险因素[J].世界华人消化杂志,2013,21(32):3561-3565.
[42] 郭建丽,徐勤,刘瑛,等.清华大学教工非酒精性脂肪肝及相关因素分析[J].中国公共卫生,2011,27(5):617-619.
[43] 延华,鲁晓岚,罗金燕,等.陕、甘两省酒精性与非酒精性脂肪肝流行病学分析[J].胃肠病学和肝病学杂志,2007,16(4):347-350,353.
[44] 胡晓娜,黄一沁,王姣锋,等.上海地区中老年人不同程度非酒精性脂肪性肝病的流行病学分析[J].老年医学与保健,2020,26(2):191-194,219.
[45] 黄一沁,胡晓娜,史冬梅,等.上海老年人非酒精性脂肪肝的流行情况及相关危险因素调查[J].老年医学与保健,2012,18(2):99-102.
[46] 夏祖宇,黄夕夏,熊文坚,等.上海市某社区老年人非酒精性脂肪性肝病患病率及危险因素分析[J].老年医学与保健,2021,27(5):987-993.
[47] 张婷,谢雪,刘玉萍,等.四川地区中老年体检人群非酒精性脂肪性肝病患病率调查及与代谢相关指标的相关性分析[J].现代预防医学,2020,47(12):2267-2271.
[48] 蔡雯,宋江美,王淑霞,等.维吾尔族人群血尿酸水平与非酒精性脂肪性肝病的关系研究[J].中国全科医学,2013,16(20):2323-2326.
[49] 闫蓉,牛春燕,田宇,等.乌鲁木齐地区汉族成人脂肪肝及其相关危险因素的多元回归分析[J].胃肠病学和肝病学杂志,2010,19(12):1120-1123.
[50] 薛黎,曹玲,孟存仁,等.乌鲁木齐市公务员非酒精性脂肪性肝病患病状况分析[J].现代检验医学杂志,2010,25(4):34-36,39.
[51] 咸亚静,刘漪,蔡雯,等.乌鲁木齐市沙依巴克区中年人群非酒精性脂肪肝患病率及影响因素分析[J].中国社会医学杂志,2018,35(5):546-549.
[52] 胡卫,杨小铭.武汉大学教职工非酒精性脂肪肝病现状及其相关危险因素分析[J].微循环学杂志,2013,23(3):40-42,46.
[53] 张利莉,袁莉,李琴,等.武汉市居民非酒精性脂肪性肝病及代谢综合征现况调查和相关性分析[J].中华全科医师杂志,2010,9(1):56-57.
[54] 于文畅,吴歌,姚铭.一汽某厂职工非酒精性脂肪肝现状及危险因素分析[J].中国临床研究,2013,26(4):348-349.
[55] 罗春华,李国静,周军,等.宜昌市职业人群非酒精性脂肪性肝病流行病学调查及其与代谢综合征相关性研究[J].重庆医学,2016,45(3):390-392.
[56] 赵辉,强艳,宋辉.银川某体检人群非酒精性脂肪肝检出水平及影响因素分析[J].宁夏医科大学学报,2018,40(10):1144-1148.
[57] 孙晋英,孙中莉.枣庄市离退休老年人非酒精性脂肪肝与代谢综合征相关性研究[J].齐鲁护理杂志,2013,19(17):64-65.
[58] 王丽萍,成志华,张学君.张家口铁路职工非酒精性脂肪性肝病流行病学调查分析[J].河北医药,2013,35(23):3634-3636.
[59] 王春萍,修桂英.长春地区健康体检人群中非酒精性脂肪肝的患病率及危险因素分析[J].中国药物经济学,2016,11(11):139-141.
[60] 谭德安,周智广,黄干,等.长沙铁路职工非酒精性脂肪肝的流行现状及危险因素分析[J].实用预防医学,2007,14(3):650-653.
[61] 吴梓苗,冯杰,张爱军.浙江省慈溪市企事业单位人员非酒精性脂肪肝患病率及危险因素分析[J].疾病监测,2014,29(8):660-664.
[62] 彭仙娥,黄之敏,林建银,等.职员非酒精性脂肪肝患病及影响因素分析[J].中国公共卫生,2009,25(10):1235-1237.
[63] 陈长喜,杜娟,徐益敏,等.中老年人非酒精性脂肪肝与糖化血红蛋白关系的流行病学研究[J].中华内科杂志,2015,54(6):517-520.
[64] 高爱滨,肖谦,李龙英,等.重庆市公务员非酒精性脂肪肝和代谢综合征的相关性调查研究[J].中华预防医学杂志,2008,42(2):107-110.
[65] HU X,HUANG Y,BAO Z,et al.Prevalence and factors associated with nonalcoholic fatty liver disease in Shanghai work-units[J].BMC Gastroenterol,2012,12:123.
[66] WANG J,CHIU W H,CHEN R C,et al.The clinical investigation of disparity of nonalcoholic fatty liver disease in a Chinese occupational population in Taipei,Taiwan:experience at a teaching hospital[J].Asia Pac J Public Health,2015,27(2):1793-1804.
[67] LI Z,XUE J,CHEN P,et al.Prevalence of nonalcoholic fatty liver disease in mainland of China:a meta-analysis of published studies[J]. J Gastroenterol Hepatol,2014,29(1):42-51.
[68] ZHOU J,ZHOU F,WANG W,et al.Epidemiological Features of NAFLD From 1999 to 2018 in China[J].Hepatology,2020,71(5):1851-1864.
[69] 李秀池,阮改清,吕加恩,等.某IT企业员工非酒精性单纯性脂肪肝和非酒精性脂肪性肝炎的初步调查及特征分析[J].临床肝胆病杂志,2017,33(7):1324-1327.
[70] PAUL S,DAVIS A M.Diagnosis and Management of Nonalcoholic Fatty Liver Disease[J].JAMA,2018,320(23):2474-2475.
[71] ADOLPH T E,GRANDER C,GRABHERR F,et al.Adipokines and Non-Alcoholic Fatty Liver Disease:Multiple Interactions[J].Int J Mol Sci,2017,18(8):1649.
[72] LIAN K,FENG Y N,LI R,et al.Middle-and high-molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease[J].J Clin Lab Anal,2020,34(4):e23148.
[73] 张会,叶茂聪,王变,等.1 431例医务人员脂肪肝患病调查及血清学特点分析[J].临床内科杂志,2020,37(12):882-883.
[74] 国家卫生健康委员会.中国居民营养与慢性病状况报告(2020年)[J].营养学报,2020,42(6):521.
[75] 金倩,杨菁,范建高.非酒精性脂肪性肝病的流行现状[J].肝脏,2021,26(1):87-88.
[76] ZHANG H J,PAN L L,MA Z M,et al.Long-term effect of exercise on improving fatty liver and cardiovascular risk factors in obese adults:A 1-year follow-up study[J].Diabetes Obes Metab,2017,19(2):284-289.
[77] 李成成,付珺,张保国,等.邢台市城市居民饮酒现状及与相关疾病的关系[J].中国慢性病预防与控制,2016,24(3):198-200.
[78] ESTES C,ANSTEE Q M,Arias-Loste M T,et al.Modeling NAFLD disease burden in China,France,Germany,Italy,Japan,Spain,United Kingdom,and United States for the period 2016-2030[J].J Hepatol,2018,69(4):896-904.