Abstract: Objective To understand the contamination status of food-borne Salmonella in Cangzhou City,explore its molecular classification and drug susceptibility,and provide scientific basis for the prevention of food-borne Salmonella diseases. Methods From 2020 to 2023,88 strains of Salmonella were typed by molecular typing,including serum typing and pulsed field gel electrophoresis（PFGE） typing,and drug resistance of strains was monitored by drug susceptibility analysis system. Results The serotypes and PFGE bands of 88 Salmonella strains showed diversity,with a total of 22 serotypes detected. Among them,Salmonella enterica and Salmonella typhimurium accounted for 30.68% and 23.86%,respectively,and were the dominant serotypes in the local area. 81 bands were obtained by PFGE typing,the similarity of cluster analysis was 53.2%-100.0%,and the dominant bands included 10 strains. There was a statistically significant difference in the resistance of 88 strains of Salmonella to different antibiotics（P<0.05）. Most of the strains had poor drug sensitivity and severe drug resistance. The proportion of multi-drug resistant strains was as high as 52.27%,the resistance rates of ampicillin,ampicillin and tetracycline were all more than 50%. Conclusion Salmonella serotypes are widely distributed in Cangzhou City,with predominant serotypes being Salmonella enterica and Salmonella typhimurium. PFGE bands are diverse,and the PFGE types of most strains of the same serotype can cluster together. Most strains are multidrug-resistant,and the problem of drug resistance is quite serious.

Key words: Salmonella, Molecular classification, Analysis of drug susceptibility results, Pulsed field gel electrophoresis, Multidrug resistance