Abstract: Objective To understand the relationship between awareness rate,access to knowledge and the level of awareness rate of hepatitis C prevention and control among different populations in Liangzhou District of Wuwei City and the occurrence of high-risk behavior of hepatitis C,so as to provide reference for the follow-up prevention and control of hepatitis C,comprehensive intervention and health promotion. Methods From April to June 2023,a combination of random cluster sampling and convenience sampling was used to conduct a questionnaire survey on the knowledge awareness rate and related behaviors of hepatitis C prevention and control among four populations in Liangzhou District：urban residents,rural residents,university students,and entertainment venue staff,and the data were analyzed. Results A total of 815 effective questionnaires were collected. The total awareness rate of hepatitis C prevention and treatment among different populations in Liangzhou District of Wuwei City was 44.42%,the correct answer rate of all 10 pieces basic knowledge survey items on hepatitis C prevention and control was 18.04%,and the incorrect answer rate was 6.99%. Univariate analysis showed that the awareness rate of hepatitis C prevention and treatment knowledge was related to different population categories,age,education level and marital status（χ²=91.623,66.441,68.776, 37.768,all P<0.05）,but not to different genders,and the difference was not statistically significant（P>0.05）. The awareness rate of college students was higher than that of other groups（OR=2.759,95%CI：1.753-4.345）,the awareness rate of 15-<31 years old was higher than that of other age groups,the awareness rate of people with college education or above was higher than that of other people（OR=7.724,95%CI：3.565-16.734）,the awareness rate of unmarried people was higher than that of other groups. The main ways for the public to acquire knowledge about the prevention and treatment of hepatitis C were through the internet,short video（70.18%）,chat,friends notifications（59.14%）,and television and radio（52.27%）. Conclusion There is still a lack of awareness among different populations in Liangzhou District of Wuwei City regarding the prevention and treatment of hepatitis C. The awareness rate of hepatitis C prevention and treatment needs to be improved urgently. In future work,efforts should be made to strengthen publicity among rural residents,low educated individuals,and middle-aged and elderly populations,enhance self-protection awareness,and reduce the phenomenon of "separation of knowledge and practice" in hepatitis C.

Key words: Liangzhou District of Wuwei City, Hepatitis C, Awareness rate, Dangerous behavior