Effectiveness and safety of EV-A71 vaccine in children：A meta-analysis

Abstract

Abstract: Objective To assess the efficacy and safety of enterovirus A71（EV-A71） vaccine in children through systematic review and meta-analysis. Methods A comprehensive search for relevant randomized controlled trials（RCTs） was conducted in PubMed,Cochrane Library,Embase,and Web of Science databases. The literature published at home and abroad since the establishment of the database until September 2023 was collected. All data were summarized using RevMan 5.3 statistical software,and risk ratios （RR） and their 95% confidence intervals were used as effect sizes. Results Six RCTs were included. The results of meta-analysis showed that the vaccine group had a higher prevention rate of EV-A71-related diseases than the placebo group（RR=0.08,95%CI：0.03-0.21,P<0.01）,with a protection effect of 92%（95%CI：79%-97%）. The vaccine group had a higher prevention rate of hospitalization for EV-A71-related diseases than the placebo group（RR=0.04,95%CI：0.01-0.20,P<0.01）,with a protection effect of 96%（95%CI：80%-99%）. The vaccine group had a higher prevention rate of developing serious complications than the placebo group（RR=0.12,95%CI：0.02-0.65,P<0.05）,with a protection effect of 88%（95%CI：35%-98%）. In the vaccine safety analysis,except for the incidence rates of irritability,drowsiness,weakness and tertiary diarrhea were higher in the vaccine group than in the placebo group,there was no significant difference in other adverse reactions,and most of them were transient and had a good prognosis. Conclusion The EV-A71 vaccine is effective in the prevention of hand,foot and mouth disease（HFMD） due to EV-A71 infection,as well as in the prevention of hospitalization and the occurrence of serious complications,while having a high safety profile.

Key words: Human enterovirus, Vaccine, Hand, foot and mouth disease, Meta-analysis

CLC Number:

R181.2

ZHAO Xiaoli, GAO Jingying, QIANG Yuehua, XING Yanbo, SHANG Mingyu. Effectiveness and safety of EV-A71 vaccine in children：A meta-analysis. [J]OCCUPATION AND HEALTH, 2024, 40(24): 3432-3436.

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