Abstract:

Objective To analyze the incidence and pathogenic characteristics of hand，foot and mouth disease（HFMD） in Binhai New Area of Tianjin City，and provide theoretical basis for the prevention and control of HFMD in the whole district. Methods Sort out the case data of HFMD in Binhai New Area of Tianjin City from 2016 to 2023，describe the distribution and epidemic characteristics. Collect stool samples from some clinically diagnosed cases of HFMD for enterovirus detection，and analyze case data and laboratory test results. Results The highest incidence rate of HFMD in Binhai New Area was 109.56 per 100 000 in 2023，the lowest was 3.18 per 100 000 in 2022. The peak season of the disease was summer and autumn. The cases were distributed in all the towns in the district，with higher reported cases in the towns with relatively dense population and integration of urban and rural areas. The average number of reported cases per year was 888 for males，which was higher than the 577 cases for females. The age group of 3-<4 years old had the highest proportion of cases，with an average of 255 cases reported annually，accounting for 23.16%. The occupation was mainly scattered children，with an average of 631 cases reported annually，accounting for 43.04%. CoxA6 enterovirus was the main epidemic strain in Binhai New Area of Tianjin City，and families and private kindergartens were high-risk areas for clustered outbreaks. Conclusion In recent years，the overall incidence of HFMD in Binhai New Area has shown a trend of high incidence every other year，with obvious seasonal，regional，and population characteristics，and the epidemic strains are relatively stable after 2018. It is suggested to strengthen monitoring，propaganda，and prevention and control guidance for key areas，key units，and key populations to avoid large-scale outbreaks and epidemics in the region. In recent years，the detection rate of EV71 in Binhai New Area has remained at a low level，the risk of severe illness and death has been greatly reduced，in the later stage，we should continuously strengthen the monitoring and pay attention to the changing trend of epidemic strains.

Key words: Hand，foot and mouth disease, Epidemic characteristics, Virus typing