Objective To assess the association between low-level welding fume exposure and arrhythmia in workers,and analyze its interaction with other occupational factors,in order to provide a theoretical basis for formulating more precise occupational health protection standards and reduce the risk of cardiovascular diseases in employees. Methods A cross-sectional study was conducted using key occupational monitoring data from 623 workers in Guangdong Province in 2023. Mixed-effects models were used to adjust for confounding factors,and stratified and interaction analyses were performed to identify susceptible populations. Results There was a significant correlation between low-level welding fume exposure and the risk of arrhythmia. For each interquartile range(IQR) increased in welding fume exposure,the risk of arrhythmia increased by 74.2%(OR=1.742,95%CI:1.292-2.348). Among the stratification factors,there was a statistically significant difference in the interaction between work duration (>2.58-5.00 years) and exposure to welding fumes(P<0.05),males(OR=1.867,95%CI:1.348-2.587),workers aged 18-41 years(OR=1.799,95%CI:1.180-2.743),those with 0.33-2.58 years of work experience(OR=3.229,95%CI:1.596-6.533),individuals with an annual household income 0-<100 000 yuan(OR=1.938,95%CI:1.357-2.767),employees of domestic-funded enterprises(OR=1.767,95%CI:1.263-2.472),and those exposed to occupational noise(OR=1.775,95%CI:1.307-2.411) were more susceptible to the adverse effects of welding fume exposure on arrhythmia(all P<0.05). Conclusion In practical occupational health monitoring,it is necessary to strengthen regular special examinations for key populations exposed to low-level welding fumes,in order to achieve early intervention and reduce the risk of cardiovascular disease of welding workers.