Research progress on the role of dietary antioxidants in obesity management

Abstract

Abstract:

As a primary risk factor for numerous chronic diseases，obesity has become a major challenge for global public health. Research indicates that its core pathophysiological mechanisms are intimately linked to the exacerbation of chronic low-grade inflammation and oxidative stress. Dietary antioxidants，such as vitamin C，vitamin E，and polyphenolic compounds，can mitigate oxidative damage，regulate metabolism，ameliorate insulin resistance，and exert anti-inflammatory effects，thus representing a potential strategy for intervening in obesity and its related metabolic complications. This article reviews the pivotal role of oxidative stress in the onset and progression of obesity，summarizes the research evidence of dietary antioxidants in clinical interventions，in order to provide reference for the prevention and treatment of obesity and related metabolic diseases through dietary approaches.

Key words: Antioxidation, Diet, Oxidative stress, Obesity, Review

CLC Number:

R153

ZHANG Yihua, WANG Xiumei, NIU Qingmei, ZHANG Qian. Research progress on the role of dietary antioxidants in obesity management. [J]OCCUPATION AND HEALTH, 2026, 42(21): 3020-3024.

References 42

[1]	World Health Organization. Prevention of cardiovascular disease:Guidelines for assessment and management of total cardiovascular risk[EB/OL]. (2007)[2025-12-20]. https://iris.who.int/handle/10665/43685.
[2]	WANG Y, ZHAO L, GAO L, et al. Health policy and public health implications of obesity in China[J]. Lancet Diabetes Endocrinol, 2021, 9(7):446-461. DOI URL
[3]	刘月姣. 《中国居民营养与慢性病状况报告(2020年)》发布[J]. 中国食物与营养, 2020, 26(12):2.
[4]	QUEK J, CHAN K E, WONG Z Y, et al. Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population:A systematic review and meta-analysis[J]. Lancet Gastroenterol Hepatol, 2023, 8(1):20-30. DOI URL
[5]	GALLO G, DESIDERI G, SAVOIA C. Update on obesity and cardiovascular risk:From pathophysiology to clinical management[J]. Nutrients, 2024, 16(16):2781. DOI URL
[6]	JANTAPE T, KONGWATTAKUL K, ARRIBAS S M, et al. Maternal obesity alters placental and umbilical cord plasma oxidative stress,a cross-sectional study[J]. Int J Mol Sci, 2024, 25(19):10866. DOI URL
[7]	CIOFFI F, GIACCO A, PETITO G, et al. Altered mitochondrial quality control in rats with metabolic dysfunction-associated fatty kiver fisease(MAFLD) induced by high-fat feeding[J]. Genes, 2022, 13(2):315. DOI URL
[8]	XIA W, VEERAGANDHAM P, CAO Y, et al. Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation[J]. Nat Metab, 2024, 6(2):273-289. DOI
[9]	陈兴光, 舒丽梅, 随伟红, 等. 黄酮类成分改善代谢综合征的作用及机制研究进展[J]. 中草药, 2025, 56(23):8803-8815.
[10]	STANEK A, GRYGIEL-GÓRNIAK B, BROŻYNA-TKACZYK K, et al. The influence of dietary interventions on arterial stiffness in overweight and obese subjects[J]. Nutrients, 2023, 15(6):1440. DOI URL
[11]	PÉREZ-TORRES I, CASTREJÓN-TÉLLEZ V, SOTO M E, et al. Oxidative stress, plant natural antioxidants,and obesity[J]. Int J Mol Sci, 2021, 22(4):1786. DOI URL
[12]	AHMED B, SULTANA R, GREENE M W. Adipose tissue and insulin resistance in obese[J]. Biomed Pharmacother, 2021, 137:111315. DOI PMID
[13]	SHI H, KOKOEVA M V, INOUYE K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance[J]. J Clin Invest, 2006, 116(11):3015-3025. DOI PMID
[14]	QING Z, XIAO H W, XI M W, et al. Vitamin C deficiency aggravates tumor necrosis factor α-induced insulin resistance[J]. Eur J Pharmacol, 2018, 829:1-11. DOI PMID
[15]	SUREN GARG S, KUSHWAHA K, DUBEY R, et al. Association between obesity,inflammation and insulin resistance:Insights into signaling pathways and therapeutic interventions[J]. Diabetes Res Clin Pract, 2023, 200:110691. DOI URL
[16]	BIZEREA-MOGA T O, PITULICE L, BIZEREA-SPIRIDON O, et al. Exploring the Link between Oxidative Stress,Selenium Levels,and Obesity in Youth[J]. Int J Mol Sci, 2024, 25(13):7276. DOI URL
[17]	MA K, ZHANG Y, ZHAO J, et al. Endoplasmic reticulum stress:Bridging inflammation and obesity-associated adipose tissue[J]. Front Immunol, 2024, 15:1381227. DOI URL
[18]	MOCHIDA K, NAKATOGAWA H. ER-phagy:Selective autophagy of the endoplasmic reticulum[J]. EMBO Rep, 2022, 23(8):e55192.
[19]	安文亭, 李众擎, 王飞, 等. 白藜芦醇通过线粒体自噬调节动物肠道氧化损伤的作用及机制[J]. 猪业科学, 2025, 42(11):72-74.
[20]	KOHLI S K, KHANNA K, BHARDWAJ R, et al. Nitric oxide,salicylic acid and oxidative stress:Is it a perfect equilateral triangle?[J]. Plant Physiol Biochem, 2022, 184:56-64. DOI URL
[21]	王芳, 周鹏, 王沛坚. 氧化应激致衰老相关内皮功能障碍及潜在的内源性可干预靶点[J]. 成都医学院学报, 2014, 9(3):362-366.
[22]	余辉, 李宾, 甘受益. LOX-1、eNOS及FFA信号通路调控冠状动脉慢血流微循环障碍的作用机制研究[J]. 中国循证心血管医学杂志, 2025, 17(2):208-212.
[23]	WANG Z, LI S, GE S, et al. Review of distribution,extraction methods,and health benefits of bound phenolics in food plants[J]. J Agric Food Chem, 2020, 68(11):3330-3343. DOI URL
[24]	MOUSAVI S M, MILAJERDI A, VARKANEH H K, et al. The effects of curcumin supplementation on body weight,body mass index and waist circumference:A systematic review and dose-response meta-analysis of randomized controlled trials[J]. Crit Rev Food Sci Nutr, 2020, 60(1):171-180. DOI URL
[25]	李益明, 张玲, 邢小珍, 等. 维生素C联合维生素E对血液透析患者抗氧化力、炎症反应状态的影响[J]. 海南医学院学报, 2017, 23(19):2635-2637,2641.
[26]	那日苏, 张海峰. 维生素C通过调节PPAR-α靶基因抑制高脂饮食诱导非酒精性脂肪肝小鼠[J]. 中国现代应用药学, 2021, 38(22):2791-2795.
[27]	周清. 维生素C改善TNF-α诱导的胰岛素抵抗的作用及其机制研究[D]. 杭州: 浙江大学, 2018.
[28]	常文露, 汪求真, 吕凯光, 等. 维生素E与镁对肥胖大鼠红细胞稳定性及抗氧化能力的影响[J]. 卫生研究, 2016, 45(6):945-950.
[29]	OJULARI O V, LEE S G, NAM J O. Therapeutic effect of seaweed derived xanthophyl carotenoid on obesity management;overview of the last decade[J]. Int J Mol Sci, 2020, 21(7):2502. DOI URL
[30]	何秀英, 薛婷, 黄惠彬. 抗氧化营养素与代谢综合征关系研究:基于孟德尔随机化[J]. 福建医药杂志, 2025, 47(2):25-30.
[31]	MAMUN M A A, RAKIB A, MANDAL M, et al. Polyphenols:Role in modulating immune function and obesity[J]. Biomolecules, 2024, 14(2):221. DOI URL
[32]	DZAH C S, ASANTE-DONYINAH D, LETSYO E, et al. Dietary polyphenols and obesity:A review of polyphenol effects on lipid and glucose metabolism,mitochondrial homeostasis,and starch digestibility and absorption[J]. Plant Foods Hum Nutr, 2023, 78(1):1-12. DOI
[33]	BURKE A C, SUTHERLAND B G, TELFORD D E, et al. Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr-/- mice[J]. J Lipid Res, 2018, 59(9):1714-1728. DOI URL
[34]	陈焱, 封俨宸, 廖紫云, 等. 葛根素调节肥胖机制的研究进展[J]. 中草药, 2025, 56(11):4103-4114.
[35]	郭玮钰, 沈浩然, 秦小静, 等. 槲皮素-3-O-β-D-葡萄糖醛酸苷通过促进白色脂肪棕色化改善高脂小鼠肥胖的作用[J]. 中国粮油学报, 2025, 40(11):75-81.
[36]	MONGIOÌ L M, LA VIGNERA S, CANNARELLA R, et al. The role of resveratrol administration in human obesity[J]. Int J Mol Sci, 2021, 22(9):4362. DOI URL
[37]	吉喆, 曹卉, 王丽, 等. 姜黄素联合有氧运动对大鼠肝脏脂肪变性的改善作用及机制[J]. 营养学报, 2025, 47(3):277-284.
[38]	WANG W, LIU L, SHAN R, et al. Associations between dietary copper intake,general obesity and abdominal obesity risk:A nationwide cohort study in China[J]. Front Nutr, 2022, 9:1009721. DOI URL
[39]	李文梅, 俞捷, 胡斌丽, 等. 凤冈锌硒茶对肥胖大鼠的清脂效果[J]. 山东医药, 2018, 58(13):31-33.
[40]	穆志丹, 梁晨, 陈名阳, 等. 锌通过调节Keap1/Nrf2/HO-1通路对肥胖小鼠肾脏损伤的影响[J]. 医学理论与实践, 2025, 38(7):1081-1085,1093.
[41]	马梦陆, 孙婉玉, 刘娟, 等. 硒麦芽面对肥胖高血糖大鼠糖脂代谢的影响[J]. 医药前沿, 2024, 14(8):13-18.
[42]	ZAVROS A, ANDREOU E, APHAMIS G, et al. The effects of zinc and selenium co-supplementation on resting metabolic rate,thyroid function,physical fitness,and functional capacity in overweight and obese people under a hypocaloric diet:A randomized,double-blind,and placebo-controlled trial[J]. Nutrients, 2023, 15(14):3133. DOI URL