Abstract: Objective To construct a game theory-based occupational health management model and verify its effectiveness. Methods From July 2021 to June 2022,a game model involving three parties at different levels was built,and the existing occupational health management work of anrefinery enterprise was optimized according to the model analysis results. The paired t test and Wilcoxon rank sum test were used to compare and analyze the changes in occupational health management before and after the establishment of the model. Results The total expected return of all parties in the game was negatively correlated with the cumulative mean of occupational health production cost input at each level. The expected return of participants was positively correlated with the detection rate of violations θ_i. The expected return of operators outside the device was negatively correlated with the assessment F₁ they may suffer. Before and after the application of the model,the total number of punishment assessment decreased by 30,the number of company-level punishment decreased by 18,the number of department-level punishment decreased by 15,and the number of reward assessment increased by 23,with statistically significant differences（P<0.05）,while the number of device-level punishment increased by 3,with no statistically significant difference（P>0.05）. Conclusion It is feasible to optimize the occupational health management of enterprises by using the game theory model,which can provide new approaches for occupational health management.

Key words: Refinery enterprise, Occupational health management, Game theory, Occupational health