Time series analysis for the influence of gaseous pollutants on the number of inpatients with coronary heart disease in Hebei District of Tianjin in 2019

Abstract

Abstract: Objective To analyze the effect and lag effect of gaseous pollutants on the number of inpatients with coronary heart disease（CHD） in Hebei District of Tianjin in 2019. Methods The concentration of gaseous pollutants，meteorological factors and relevant information of inpatients with CHD in Tianjin Fourth Central Hospital from January 1，2019 to December 31，2019 were collected. The effect of gaseous pollutants on the number of inpatients with CHD was analyzed by generalized additive model. Results The average daily concentrations of gaseous pollutants NO₂，O₃，SO₂ and CO in Hebei District of Tianjin in 2019 were 42.17μg/m³，106.23 μg/m³，10.85 μg/m³ and 0.96 mg/cm³. According to the secondary concentration limit specified in the Ambient Air Quality Standard（GB 3095-2012），NO₂ exceeded the standard for 164 days，with theoverstandard rate of 44.93%. The O₃ exceeded the standard for 81 days，and the overstandard rate was 22.19%. Neither SO₂ nor CO exceeded the standard. The effect of NO₂ concentration increasing by 10 μg/m³ on the number of inpatients with CHD reached the maximum after 1 day lag，theexcess rish（ER） value was 3.35（95%CI：0.28-6.52），and the difference was statistically significant（P<0.05）. The effect of O₃ concentration increasing by 10 μg/m³ on the number of inpatients with CHD reached the maximum when the delay was 7 days，the ER value was -1.28（95%CI：-2.29--0.25），and the difference was statistically significant（P<0.05）. The increase of CO and SO₂ concentration had no effect on the number of inpatients with CHD. Conclusion The elevated concentration of gaseous pollutant NO₂ in Hebei District of Tianjin in 2019 may lead to an increase in the risk of hospitalization for CHD among residents，and it is of great significance to control gaseous pollutants for reducing the hospitalization risk of CHD.

Key words: Gaseous pollutants, Coronary heart disease, Hospitalization

CLC Number:

R181.3⁺4

LI Mei, ZHANG Jing-wei, DU Juan. Time series analysis for the influence of gaseous pollutants on the number of inpatients with coronary heart disease in Hebei District of Tianjin in 2019. [J]OCCUPATION AND HEALTH, 2023, 39(2): 243-246.

References

[1] 于艳华,谢文瑞.冠心病患者NLR及BMP4、ANGPLT8水平检测的临床意义[J].检验医学与临床,2022,19(14):1961-1965.
[2] ROTH G A,MENSAH G A,JOHNSON C O,et al.Global burden of cardiovascular diseases and risk factors,1990-2019:update from the GBD 2019 study[J].J Am Coll Cardiol,2020,76(25):2982-3021.
[3] GUO M L,GUO L L,QIN Q J,et al.The molecular mechanism of serum microRNA124b induced coronary heart disease by inducing myocardial cell senescence[J].Eur Rev Med Pharmacol Sci,2018,22(10):2913.
[4] 华琨,罗忠伟,贾斌,等.天津市空气污染的健康影响分析[J].环境科学,2022:1-15(2022-08-30)[2022-12-12].https://doi.org/10.13227/j.hjkx.202205088.10.13227/j.hjkx.202205088.
[5] 中华人民共和国生态环境部.2017-2020年中国生态环境状况公报[EB/OL].(2021-05-27)[2022-08-12].http://www.cnemc.cn/jcbg/zghjzkgb/.
[6] 张钊铭,刘玟彤,周丽婷,等.长春市大气污染与冠心病住院人次的关联性[J].中国老年学杂志,2020,40(7):1345-1349.
[7] ATKINSON R W,BUTLAND B K,ANDERSON H R,et al.Long-term concentrations of nitrogen dioxide and mortality:a meta-analysis of cohort studies[J].Epidemiology,2018,29(4):460-472.
[8] CHEN J,HOEK G.Long-term exposure to PM and all-cause and cause-specific mortality:a systematic review and meta-analysis[J].Environ Int,2020,143:105974.
[9] CHEN K,WOLF K,BREITNER S,et al.Two-way effect modifications of air pollution and air temperature on total natural and cardiovascular mortality in eight European urban areas[J].Environ Int,2018,116:186-196.
[10] 中华人民共和国生态环境部.2019中国生态环境状况公报发布[R].北京:中华人民共和国生态环境部,2020.
[11] 余益军,孟晓艳,王振,等.京津冀地区城市臭氧污染趋势及原因探讨[J].环境科学,2020,41(1):106-114.
[12] 李慧,王淑兰,张文杰,等.京津冀及周边地区“2+26”城市空气质量特征及其影响因素[J].环境科学研究,2021,34(1):172-184.
[13] PEUY,JIANG R,ZOU Y,et al.Effects of fine particulate matter (PM_2.5) on systemic oxidative stress and cardiac function in ApoE(-/-) mice[J].Int J Environ Res Public Health,2016,13(5):484.
[14] DE OLIVEIRA-FONOFF A M,MADY C,PESSOA F G,et al.The role of air pollution in myocardial remodeling[J].PLoS One,2017,12(4):e0176084.
[15] ZHANG J J,CUI M M,FAN D,et al.Relationship between haze and acute cardiovascular,cerebrovascular,and respiratory diseases in Beijing[J].Environ Sci Pollut Res Int,2015,22(5):3920-3925.
[16] 陈则圣,崔秀青,王斌,等.大气低污染水平NO₂对居民心脑血管疾病死亡影响的时间序列研究[J].公共卫生与预防医学,2022,33(1):27-31.
[17] LI W,CAO Y,LI R,et al.The spatial variation in the effects of air pollution on cardiovascular mortality in Beijing,China[J].J Expo Sci Environ Epidemiol,2018,28(3):297-304.
[18] 项晓铭,崔珍珍,张浩,等.中国重点城市NO₂排放规律与驱动分析[J].环境科学与技术,2022,45(7):30-45.
[19] 顾怡勤,陈仁杰.大气颗粒物与上海市闵行区居民心脑血管疾病死亡的病例交叉研究[J].环境与职业医学,2017,34(3):220-223.
[20] 张婉怡,刘畅,张武,等.佳木斯市大气PM10对呼吸系统疾病日入院人数的影响[J].环境与健康杂志,2017,34(2):135-138.
[21] QIAO L,CAI J,WANG H,et al.PM_2.5 constituents and hospital emergency-room visits in Shanghai,China[J].Environ Sci Technol,2014,48(17):10406-10414.
[22] DUAN Y,LIAO Y,LI H,et al.Effect of changes in season and temperature on cardiovascular mortality associated with nitrogen dioxide air pollution in Shenzhen,China[J].Sci Total Environ,2019,697:134051.
[23] STIEB D M,BERJAWI R,EMODE M,et al.Systematic review and meta-analysis of cohort studies of long term outdoor nitrogen dioxide exposure and mortality[J].PLoS One,2021,16(2):e0246451.
[24] 肖致美,李亚菲,高璟赟,等.2013~2020年天津市PM2.5-O3污染变化趋势和影响因素分析[J].环境科学,2022:1-13(2022-11-18)[2022-12-14].https://doi.org/10.13227/j.hjkx.202210215.10.13227/j.hjkx.202210215.
[25] 宋小涵,燕丽,刘伟,等.2015—2021年京津冀及周边地区PM_2.5和臭氧复合污染时空特征分析[J].环境科学,2022:1-17(2022-08-02)[2022-12-15].https://doi.org/10.13227/j.hjkx.202205089.10.13227/j.hjkx.202205089.
[26] DICKERSON R R,KONDRAGUNTA S,STENCHIKOV G,et al.The impact of aerosols on solar ultraviolet radiation and photochemical smog[J].Science,1997,278(5339):827-830.
[27] 寇新荣,恽朝晖,杨凯璇,等.沈阳市铁西区大气PM_2.5对冠心病住院的影响[J].环境与健康杂志,2019,36(3):227-231.