职业性哮喘, 动脉粥样硬化, 血脂, C 反应蛋白, 同型半胱氨酸, 尿酸, 糖化血红蛋白, 颈动脉内膜中层厚度, 踝臂指数

Objective To observe the changes of atherosclerosis related indexes in patients with occupational asthma （OA）.Methods From July 2017 to June 2018， 102 OA patients were selected as the case group （they were divided into mild<5 years subgroup， mild≥5 years subgroup， moderate-severe<5 years subgroup and moderate-severe≥5 years subgroup according to the course and severity of disease）， while 30 healthy adults served as control group. Color Doppler ultrasound， arteriosclerosis detector and biochemical detector were used to test the total cholesterol（TC）， triglyceride（TG）， high density lipoprotein cholesterol （HDL-C）， C-reactive protein （CRP）， homocysteine （Hcy）， serum uric acid （UA）， glycosylated hemoglobin （HbA1c）， carotid intima-media thickness（IMT） and ankle brachial index（ABI）. Results Inflammatory cytokine and other indexes: Compared with the control group， CRP level in the four subgroups of the case group were increased. Except for the mild <5year subgroup， the levels of TC， LDL-C， TG and HCY in the other three subgroups were increased， while HDL-C levels were decreased. Among subgroups， the levels of TC， LDL-C， TG and CRP in severe illness or long course groups were increase， while HDL-C levels were decreased. All differences were statistically significant（P<0.05）. Atherosclerosis indexes: Compared to the control group， IMT level and IMT abnormal rate in mild ≥5 years subgroup and two moderate-severe subgroups were increased， while ABI level in two moderate-severe subgroups were decreased. Among subgroups， IMT level in severe illness or long course groups were increased. All differences were statistically significant（P<0.05）. Conclusion The atherosclerosis related indexes in patients with OA are increased or abnormal， and aggravated with the extension of course and severity of illness.

Occupational asthma, Atherosclerosis, Blood lipid, C-reactive protein, Homocysteine, Uric acid, Glycosylated

hemoglobin, Carotid intima-media thickness, Ankle brachial index