circRNAs 作为疾病潜在生物标志物的研究进展

摘要/Abstract

摘要：

环状RNA（circular RNAs，circRNAs）是一种存在于生物体中闭合环结构的RNA分子，由于这种独特的环状结构，与线性RNA相比环状RNA更稳定，具有多样性、普遍性、稳定性、特异性及保守性等特点。目前临床上有许多疾病被发现时处于疾病中晚期，错过了疾病最佳治疗时间。已有大量文献报告circRNAs可稳定地存在于体液中，并且其差异表达与多种疾病的发生发展密切相关。因此，体液中circRNAs具有作为疾病诊断新型生物标志物的潜能，本文就各种疾病状态下体液中circRNAs的差异表达作一综述。

关键词: circRNAs, 稳定, 体液, 疾病, 生物标志物

Abstract:

The circular RNA（circRNAs） is a unique type of RNA molecule by a closed loop structure present in various organisms.This circular configuration imparts greater stability to circRNAs compared to linear RNA，and it showcases traits such as diversity，universality，stability，specificity and conservatism.In clinical settings，diseases are often diagnosed at advanced stages，missing the optimal treatment window.Numerous studies have shown that circRNAs can be detected in body fluids，and their unique expression profiles are closely linked to disease progression.Therefore，circRNAs present in body fluids hold promise as a novel biomarker for disease diagnosis.This paper provides a comprehensive review of the differential expression levels of circRNAs in body fluids across various disease states.

Key words: circRNAs, Stability, Body fluid, Disease, Biomarker

中图分类号:

R446

刘婷, 洪叶挺, 童武林, 吴建荣, 周洁, 张伟群. circRNAs 作为疾病潜在生物标志物的研究进展. [J]职业与健康, 2026, 42(12): 1697-1702.

LIU Ting, HONG Yeting, TONG Wulin, WU Jianrong, ZHOU Jie, ZHANG Weiqun. Research progress of circRNAs as potential biomarkers of disease. [J]OCCUPATION AND HEALTH, 2026, 42(12): 1697-1702.

图/表 1

参考文献 64

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样本类型	circRNA	疾病	表达量	疾病临床相关性
外周血	hsa_circ_0001785/Hsa_circ_0026352	乳腺癌	上调/下调	组织学分级、TNM分期和远处转移/CA153水平负相关
外周血	hsa_circ_0001715、hsa_circ_0000190、circRNA-002178、 hsa_circ_0046264、hsa_circ_0001715、hsa_circ_0000190、 circRNA-002178、hsa_circ_0046264、circHIPK3、 hsa_circ_0008234（circFOXP1）	肺癌	上调	早期诊断、与肿瘤大小、组织学类型和预后相关
外周血	hsa_circRNA_103809、hsa_circ_0001821、circ_0000437、 circMED27、hsa_circ_0005986、circRNA_101237 / circSMARCA5、hsa_circ_0028861、hsa_circ_0064286、hsa_ circ_000475	肝癌	上调/下调	早期诊断、与TNM分期、分化程度、肿瘤大小等有关/与 ALT、AST、ALP、AFP、胆红素等水平呈负相关
外周血	circIFT80、circ-ccdc6c、cir-c-ABCC1、circ-stil	结直肠癌	上调	早期诊断、与CEA和CA19-9结合可能提高CRC的诊断能力
外周血	hsa_circ_0000437、hsa_circ_0000190、has_circ_0141633、hsa_circ_0000437、hsa_circ_0021087、hsa_circ_0005051	胃癌	上调	早期诊断、与肿瘤直径、淋巴转移、TNM分期、CA19-9 水平相关
外周血	circFoxO3a	宫颈癌	下调	与间质浸润深浅以及淋巴结转移有关
外周血	circ-LDLRAD3、circ-BCAS3	胰腺癌	上调	早期诊断、与胰腺癌患者的静脉浸润、淋巴浸润和转移相关
外周血	circFNDC3B	甲状腺癌	上调	与疾病进展有关
外周血	circBNC2	卵巢癌	上调	早期诊断
外周血	hsa_circ_0000885、hsa_ circ_0005721	骨肉瘤	上调	早期诊断
外周血	hsa_circ_0001380	活动性肺结核	下调	对于肺结核诊断和疗效监测
外周血	circRNA_0068481	肺动脉高压	上调	预测肺动脉高压患者右心室肥厚
外周血	circRNA0044073	动脉粥样硬化	上调	促进了人血管平滑肌细胞和人血管内皮细胞的增殖
外周血	circRNA_0010551、circRNA_0060745	急性心肌梗死	上调	对老年人急性心肌梗死诊断及预测心血管疾病
外周血	circ_0051386、circ-0020887、circ-0009590	STEMI	上调	诊断和预测患者短期不良心血管预后
外周血	circ_003416/circ_005372	先天性心脏病	下调/上调	与氧化磷酸化和紧密连接信号通路的变化有关
外周血	circ_0000284	高血压	上调	早期诊断，高血压的独立危险因素
外周血	circHIPK2	重度抑郁症	上调	抗抑郁作用有预测价值
外周血	hsa_circRNA_404013	过敏性鼻炎	上调	与过敏性鼻症状及BDNF的表达水平呈正相关
外周血	hsa_circRNA_0039480、hsa_circRNA_0026497	妊娠期糖尿病	上调	早期诊断
外周血	circ_0040929	慢阻肺	上调	早期诊断
外周血	hsa_circRNA_100632	1型糖尿病	上调	早期诊断
外周血	circ-VIM/circ_0004277、circ-HIPK2	AML	上调/下调	早期诊断，预后不良的独立危险因素/化疗病情监测
尿液	hsa_circ_0001250	特发性膜性肾病	上调	与24 h尿蛋白定量水平呈正相关
尿液	circTRPS1	膀胱癌	上调	与临床分期呈正相关
尿液	circ_0004296	前列腺癌	下调	早期诊断
唾液	hsa_circ_0001874/hsa_circ_0001971	口腔鳞状细胞癌	上调/下调	TNM分期和肿瘤分级有关
滑膜液	circZNF652	骨关节炎	上调	与PTEN、MMP13和NF-KB mRNA呈正相关
肺泡灌洗液	circZNF652	儿童哮喘/炎症	上调/下调	对哮喘患儿病情判定、疾病发展/缓解脂多糖诱导的炎症损伤

样本类型	circRNA	疾病	表达量	疾病临床相关性
外周血	hsa_circ_0001785/Hsa_circ_0026352	乳腺癌	上调/下调	组织学分级、TNM分期和远处转移/CA153水平负相关
外周血	hsa_circ_0001715、hsa_circ_0000190、circRNA-002178、 hsa_circ_0046264、hsa_circ_0001715、hsa_circ_0000190、 circRNA-002178、hsa_circ_0046264、circHIPK3、 hsa_circ_0008234（circFOXP1）	肺癌	上调	早期诊断、与肿瘤大小、组织学类型和预后相关
外周血	hsa_circRNA_103809、hsa_circ_0001821、circ_0000437、 circMED27、hsa_circ_0005986、circRNA_101237 / circSMARCA5、hsa_circ_0028861、hsa_circ_0064286、hsa_ circ_000475	肝癌	上调/下调	早期诊断、与TNM分期、分化程度、肿瘤大小等有关/与 ALT、AST、ALP、AFP、胆红素等水平呈负相关
外周血	circIFT80、circ-ccdc6c、cir-c-ABCC1、circ-stil	结直肠癌	上调	早期诊断、与CEA和CA19-9结合可能提高CRC的诊断能力
外周血	hsa_circ_0000437、hsa_circ_0000190、has_circ_0141633、hsa_circ_0000437、hsa_circ_0021087、hsa_circ_0005051	胃癌	上调	早期诊断、与肿瘤直径、淋巴转移、TNM分期、CA19-9 水平相关
外周血	circFoxO3a	宫颈癌	下调	与间质浸润深浅以及淋巴结转移有关
外周血	circ-LDLRAD3、circ-BCAS3	胰腺癌	上调	早期诊断、与胰腺癌患者的静脉浸润、淋巴浸润和转移相关
外周血	circFNDC3B	甲状腺癌	上调	与疾病进展有关
外周血	circBNC2	卵巢癌	上调	早期诊断
外周血	hsa_circ_0000885、hsa_ circ_0005721	骨肉瘤	上调	早期诊断
外周血	hsa_circ_0001380	活动性肺结核	下调	对于肺结核诊断和疗效监测
外周血	circRNA_0068481	肺动脉高压	上调	预测肺动脉高压患者右心室肥厚
外周血	circRNA0044073	动脉粥样硬化	上调	促进了人血管平滑肌细胞和人血管内皮细胞的增殖
外周血	circRNA_0010551、circRNA_0060745	急性心肌梗死	上调	对老年人急性心肌梗死诊断及预测心血管疾病
外周血	circ_0051386、circ-0020887、circ-0009590	STEMI	上调	诊断和预测患者短期不良心血管预后
外周血	circ_003416/circ_005372	先天性心脏病	下调/上调	与氧化磷酸化和紧密连接信号通路的变化有关
外周血	circ_0000284	高血压	上调	早期诊断，高血压的独立危险因素
外周血	circHIPK2	重度抑郁症	上调	抗抑郁作用有预测价值
外周血	hsa_circRNA_404013	过敏性鼻炎	上调	与过敏性鼻症状及BDNF的表达水平呈正相关
外周血	hsa_circRNA_0039480、hsa_circRNA_0026497	妊娠期糖尿病	上调	早期诊断
外周血	circ_0040929	慢阻肺	上调	早期诊断
外周血	hsa_circRNA_100632	1型糖尿病	上调	早期诊断
外周血	circ-VIM/circ_0004277、circ-HIPK2	AML	上调/下调	早期诊断，预后不良的独立危险因素/化疗病情监测
尿液	hsa_circ_0001250	特发性膜性肾病	上调	与24 h尿蛋白定量水平呈正相关
尿液	circTRPS1	膀胱癌	上调	与临床分期呈正相关
尿液	circ_0004296	前列腺癌	下调	早期诊断
唾液	hsa_circ_0001874/hsa_circ_0001971	口腔鳞状细胞癌	上调/下调	TNM分期和肿瘤分级有关
滑膜液	circZNF652	骨关节炎	上调	与PTEN、MMP13和NF-KB mRNA呈正相关
肺泡灌洗液	circZNF652	儿童哮喘/炎症	上调/下调	对哮喘患儿病情判定、疾病发展/缓解脂多糖诱导的炎症损伤