Current status and future challenges of SARS-CoV-2 detection based on SERS,lateral flow immunoassay and its combined technology

Abstract

Abstract: ：The severe acute respiratory syndrome coronavirus（SARS-CoV-2） is highly contagious,posing a great threat to human life and security. The early and rapid diagnosis of SARS-CoV-2 plays an important role in fighting outbreaks,and there is an urgent need for a rapid,sensitive and inexpensive test system. The surface-enhanced raman scattering（SERS）,as a cutting-edge analytical technique,has the ability of fingerprint recognition,which can provide quantitative results with high specificity,sensitivity and multiple detection,and has broad prospects in the immediate diagnosis of viruses.It has been applied in the detection of various influenza virus subtypes. The lateral flow immunoassay（LFIA） and other point of care（POC） devices provide a fast,efficient and reliable platform.However,LFIA has limitations in quantitative and sensitive analysis of SARS-CoV-2 detection.To solve these problems,we review the combination of SERS technology and LFIA in current status and future challenges of the quantitative analysis of SARS-CoV-2.

Key words: Surface-enhanced raman scattering, Severe acute respiratory syndrome coronavirus, Lateral flow immunoassay, Future challenges

CLC Number:

R373.1⁺9

ZHENG Zhi-heng, ZHANG Jin, LIU Yan-kun, WANG Zhi-wu, LI Jing-wu, WU Zhen-gang. Current status and future challenges of SARS-CoV-2 detection based on SERS,lateral flow immunoassay and its combined technology. [J]OCCUPATION AND HEALTH, 2023, 39(10): 1421-1425.

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