Abstract: Objective To examine the current status and influencing factors of occupational well-being of medical staff in 21 medical and nursing institutions of Guizhou Province,provide scientific reference for stabilizing the talent team of medical and nursing institutions. Methods The convenience sampling method was used to select 257 medical workers from 21 medical and nursing institutions in eight cities and states of Guizhou Province from January to March 2022 as the research object,and a survey was conducted using the general situation questionnaire and medical worker's occupational well-being scale.The descriptive analysis of general data characteristics and occupational well-being scores of medical workers was performed,the univariate factor analysis was performed using t-test and analysis of variance,and multivariate linear regression analysis were used to analyze influencing factors. Results The total score of occupational well-being of medical workers from 21 medical and nursing institutions was （81.75±18.63）points. The univariate factor analysis showed that there were statistically significant differences in occupational well-being among medical staff in different gender,workload,self-rated health status and whether the unit provided mental health guidance（all P<0.05）.The multiple regression analysis showed that gender,age,economic income,educational level,self-rated health status and whether the unit provided mental health guidance were the main influencing factors of occupational well-being of medical staff in medical and nursing institutions（all P<0.05）. Conclusion The occupational well-being of medical staff in 21 medical and nursing institutions of Guizhou Province needs to be further improved,and institutional managers should pay attention to key groups according to the influencing factors of occupational well-being,provide support and help to improve their occupational well-being.

Key words: Medical and nursing institutions, Medical staff, Occupational well-being, Influencing factors