Analysis on influence of free vaccination strategy of varicella on epidemiological characteristics of varicella in Nanjing City

Abstract

Abstract: Objective To analyze the epidemiological characteristics of varicella in Nanjing City from 2014 to 2021 and possible influence of varicella vaccine included in the Nanjing immunization plan in November 2018. Methods The descriptive epidemiological methods was used to analyze the incidence of varicella in Nanjing City from 2014 to 2021,and χ² test was used to analyze the changes in incidence rate. The spatial autocorrelation analysis of incidence rate in different regions of Nanjing City was carried out by using ArcGIS to calculate Moran's I. Results From 2014 to 2021,totally 76 707 varicella cases and 83 varicella outbreaks were reported in Nanjing City. The average incidence rate before and after the varicella vaccine included in the immunization plan was 172.021/100 000 and 154.972/100 000 respectively,and the difference was statistically significant（χ²=205.157,P<0.05）.The number of outbreaks and related cases has declined since 2019,from 29 outbreaks and 681 cases in 2019 to 5 outbreaks and 160 cases in 2021. The proportion of public health emergencies caused by varicella to total public health emergencies has also decreased from 48.98% in 2018 to 35.71% in 2021. The peaks of incidence occurred from May to June and from November to December. The winter peak in 2021 was the lowest since 2017,which was only the same as the peak from May to June of that year. The cases mainly occurred in preschool children and students aged 0-<11 years old. However,the incidence rate of children aged 0-<5 and 6-<10 years old decreased by 72.64% and 64.97% respectively as compared with 2018. The spatial aggregation was only observed in 2020 and 2021,and the Moran's I was 0.291 and 0.258 respectively. Conclusion The incidence rate of varicella significantly reduced after varicella vaccine included in the immunization plan,and it is necessary to increase the publicity efforts for the vaccination program of varicella vaccine and increase the coverage rate of varicella vaccine.

Key words: Varicella, Vaccine, Epidemiological characteristics

CLC Number:

R181.3

GU Runhui, WU Rong, DING Songning, MA Tao, WANG Hengxue, DING Jie. Analysis on influence of free vaccination strategy of varicella on epidemiological characteristics of varicella in Nanjing City. [J]OCCUPATION AND HEALTH, 2023, 39(15): 2059-2063.

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