Visualization analysis of depression project funded by National Natural Science Foundation of China：Based on CiteSpace

Abstract

Abstract: Objective Based on the support of the National Natural Science Foundation of China（NSFC） in the field of depression from 2011 to 2021,the research hotspots were analyzed in order to provide references for future research. Methods Comprehensively search NSFC official website,NSFC searching website,and LetPub database,query the related research on depression from 2011 to 2021,extract the approved year,funding type,province,et al for statistical analysis and visualization. Results From 2011 to 2021,there were a total of 1 390 grants in the field of depression,with a funding amount of 671.92 million yuan,showing a fluctuating upward trend,involving eight major academic departments and 54 first level disciplines,showing a trend of multidisciplinary joint development,and characterized by the continuous application of new technologies and methods. The regional distribution was uneven,with comprehensive universities（34.3%） and Western medicine universities（19.01%） as the main supporting units. Traditional Chinese medicine research had emerged in various units. The research mainly focuses on keywords such as synaptic plasticity,neural circuits,machine learning,and acupuncture techniques. Conclusions NSFC funding analysis helps to clarify the current hotspots of depression research and provide direction for future workers. At the same time,it enhances strengths and complements weaknesses,solidly learns relevant new theories,fully utilizes new technologies and methods,highlights disciplinary characteristics,and further enriches the scientific connotation of the field of depression.

Key words: National Natural Science Foundation of China, Depression, CiteSpace, Visualization analysis

CLC Number:

R181.2

ZHONG Dixiang, HONG Ting, QI Yuanyuan, CHU Zheyou, AO Yixuan, MIAO Yingchun. Visualization analysis of depression project funded by National Natural Science Foundation of China：Based on CiteSpace. [J]OCCUPATION AND HEALTH, 2023, 39(17): 2411-2416.

References

[1] 曾学军,张昀.协和全科医师手册[M].北京:中国协和医科大学出版社,2019:655.
[2] 杨幸. 脱产备考生心理控制感与其抑郁变化轨迹的关系[D].青海:青海师范大学,2022.
[3] 郝伟,陆林.精神病学[M].8版.北京:人民卫生出版社,2018:105.
[4] American Psychiatric Association.Diagnostic and statistical manual of mental disorders[M].5th ed.Washington DC:American Psychiatric Association Publishing,2013.
[5] 李凌江,马辛.中国抑郁障碍防治指南[M].北京:中华医学电子音像出版社,2015:2.
[6] HUANG Y Q,WANG Y,WANG H,et al.Prevalence of mental disorders in China:A cross-sectional epidemiological study[J].The Lancet Psychiatry,2019,3(6):211-224.
[7] REIBLING N,BECKFIELD J,HUIJTS T,et al.Depressed during the depression:Has the economic crisis affected mental health inequalities in Europe? Findings from the European Social Survey(2014) special module on the determinants of health[J].Eur J Public Health,2017, 27(suppl_1):47-54.
[8] GREENBERG P E,FOURNIER A A,SISITSKY T,et al.The economic burden of adults with major depressive disorder in the United States (2005 and 2010)[J].J Clin Psychiatry,2015,76(2):155-162.
[9] 唐启盛. 抑郁障碍中西医研究进展述评[J].北京中医药大学学报,2022,45(9):871-877.
[10] 刘宁,吴美平,陈婷,等.国家自然科学基金中医学领域项目2018年度申请与资助情况评述[J].中医杂志,2019,60(6):482-484,508.
[11] 曹传东,黄玉凤,韦艳艳,等.中医科研的思路与方法探讨——基于2017年医学类国家自然科学基金项目分析[J].医学与哲学,2019, 40(14):69-72.
[12] 肖志鸿,杨爽,刘流,等.国家自然科学基金资助的医学院校中医药学科研竞争力分析[J].中华医学图书情报杂志,2021,30(7):24-30.
[13] 张志雄,周乐.生理学[M].3版.上海:上海科学技术出版社,2017:243.
[14] VITUREIRA N,DE P R,LEÃO R M,et al.Editorial:Cellular and molecular mechanisms of synaptic plasticity at hippocampal and cortical synapses[J].Front Cell Neurosci,2022,16:980623.
[15] REN F,GUO R.Synaptic microenvironment in depressive disorder:Insights from synaptic plasticity[J].Neuropsychiatr Dis Treat,2021,17:157-165.
[16] ZANOS P,GOULD T D.Mechanisms of ketamine action as an antidepressant[J].Mol Psychiatry,2018,23:801-811.
[17] KRZYSTYNIAK A,BACZYNSKA E,MAGNOWSKA M,et al.Prophylactic ketamine treatment promotes resilience to chronic stress and accelerates recovery:Correlation with changes in synaptic plasticity in the CA3 subregion of the hippocampus[J].Int J Mol Sci,2019,20:1726.
[18] YAO N,SKITEVA O,ZHANG X,et al.Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit[J].Mol Psychiatry,2018,23(10):2066-2077.
[19] 王广燕,刘小艳,于党波,等.抑郁症神经环路研究进展[J].医学综述,2022,28(13):2630-2634.
[20] GORDANA N E,MARINA S,MATEA N P,et al.Depression:Biological markers and treatment[J].Prog Neuropsychopharmacol Biol Psychiatry,2021,105:110139.
[21] DEO R C.Machine learning in medicine[J].Circulation,2015,132(20):1920-1930.
[22] 廖华龙,曾小茜,李华凤,等.机器学习在疾病预测中的应用[J].生物医学工程研究,2021,40(2):203-209.
[23] KOMATSU H,WATANABE E,FUKUCHI M.Psychiatric neural networks and precision therapeutics by machine learning[J].Biomedicines,2021,9(4):403.
[24] PRUNESKI J A,WILLIAMS R J,NWACHUKWU B U,et al.The development and deployment of machine learning models[J].Knee Surg Sports Traumatol Arthrosc,2022,30(12):3917-3923.
[25] QASEEM A,BARRY M J,KANSAGARA D.Clinical guidelines committee of the american college of physicians.Nonpharmacologic versus pharmacologic treatment of adult patients with major depressive disorder:A clinical practice guideline from the American College of Physicians[J].Ann Intern Med,2016,164(5):350-359.
[26] RAVINDRAN A V,BALNEAVES L G,FAULKNER G,et al.Canadian Network for Mood and Anxiety Treatments(CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder:Section 5.Complementary and alternative medicine treatments[J].Focus (Am Psychiatr Publ),2018,16(1):85-94.
[27] 张东淑,黄凤,何伟明,等.“十二五”期间国家自然科学基金针灸学领域项目情况回顾与分析[J].中医杂志,2017,58(4):271-275.
[28] KC D,SUMNER R,LIPPMANN S.Gut microbiota and health[J].Postgrad Med,2020,132(3):274.
[29] VENDRIK K E W,OOIJEVAAR R E,DE JONG P R C,et al.Fecal microbiota transplantation in neurological disorders[J].Front Cell Infect Microbiol,2020,10:98.
[30] CAPUCO A,URITS I,HASOON J,et al.Gut microbiome dysbiosis and depression:A comprehensive review[J].Curr Pain Headache Rep,2020, 24(7):36.
[31] 汤倩倩,曹丽华.肠道菌群与神经系统疾病[J].生物工程学报,2021, 37(11):3757-3780.
[32] RATHOUR D,SHAH S,KHAN S,et al.Role of gut microbiota in depression:Understanding molecular pathways,recent research,and future direction[J].Behav Brain Res,2023,436:114081.
[33] SHADRINA M,BONDARENKO E A,SLOMINSKY P A.Genetics factors in major depression disease[J].Front Psychiatry,2018,9:334.
[34] UCHIDA S,YAMAGATA H,SEKI T,et al.Epigenetic mechanisms of major depression:Targeting neuronal plasticity[J].Psychiatry Clin Neurosci,2018,72(4):212-227.
[35] ALSHAYA D S.Genetic and epigenetic factors associated with depression:An updated overview[J].Saudi J Biol Sci,2022,29(8):103311.
[36] APPELBAUM L G,SHENASA M A,STOLZ L,et al.Synaptic plasticity and mental health:Methods,challenges and opportunities[J].Neuropsychopharmacol,2023,48(1):113-120.
[37] BLUMBERGER D M,VILA-RODRIGUEZ F,THORPE K E,et al.Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression(THREE-D):A randomised non-inferiority trial[J].Lancet,2018,391(10131):1683-1692.