Abstract: Objective Based on different risk assessment models,to evaluate the occupational health risks in synthetic leather manufacturing enterprises,comparethe differences of risk assessment models,discussthe risk assessment models for chemical harmful factors in synthetic leather manufacturing enterprises,and put forwardthe appropriate control and protection measures. Methods From May 2017 to June 2022,the synthetic leather manufacturing enterprises in a park in Taizhou City of Zhejiang Province were selected to evaluate the chemical harmful factors by using three risk assessment models at home and abroad through on-site sanitary survey and occupational disease factor detection. Results The main occupational hazard factors of synthetic leather manufacturing enterprises included dimethylformamide,benzene series,acid esters and ketones. The exposure positions mainly include dry batching,dry coating table,dry laminating,wet batching,wet coating table,three-plate batching and three-plate coating table. In the US Environmental Protection Agency occupational health inhalation risk assessment model,the hazard index of dimethylformamide exposed to dry coating station,dry fitting station,wet coating station and three-plate coating station were 239.73,242.47,99.89 and 115.48,respectively. The severity-probability combination of the most serious consequences in the romanian occupational accident and occupational disease risk assessment model was （7,3）,and the risk index in the semi-quantitative risk assessment model（composite index method） was 4. The risk assessment results of all three models were at high risk levels. The intra-group correlation coefficient was 0.400,and the consistency was medium. Conclusions The three models can be used to evaluate the occupational health risk of chemical harmful factors in synthetic leather manufacturing enterprises. Compared with the other two models,the semi-quantitative risk assessment model（comprehensive index method） has more comprehensive input factors and less subjective cognition influence,so it is more applicable.

Key words: Occupational health, Risk assessment, Synthetic leather manufacturingenterprises, Chemical hazards agents