Abstract: Objective To investigate the status quo of mental resilience in operating room nurses of Hebei Veterans General Hospital and Xingtai People's Hospital and the mediating role of mental resilience in job boredom and subjective well-being. Methods From January 2020 to January 2021，140 nurses working in the operating room of the Hebei Veterans General Hospital and Xingtai People's Hospital were collected by the random sampling method as the research objects.The Connor-Davidson resilience scale（CD-RISC），nurses' job boredom questionnaire，sub-scale of work fatigue characteristics of nurses' work fatigue questionnaire，general well-being schedule（GWB） were used respectively to assess the mental resilience，job boredom and subjective well-being of nurses. Results The score of CD-RISC，job boredom scale and GWB of operating room nurses was （59.46±6.35），（31.43±3.54） and （62.39±5.39）points，respectively.There were statistically significant differences in the mental resilience scores among nurses with different age，educational background，marital status，department working years，professional title，economic income and personnel relationship（all P<0.01）. The mental resilience was positively correlated with years of working in the department and GWB（r=0.297，0.473，both P<0.05），and negatively correlated with job boredom（r=-0.073，P<0.05）.The mental resilience played a mediating role between job boredom and subjective well-being，the direct effect value was -0.53，the indirect effect value was -0.13，and the total effect value was -0.66. Conclusions The job boredom degree of operating room nurses in two hospitals of Hebei Province is high，and the level of mental resilience and subjective well-being is low. The hospital administrator should take sufficient personalized intervention，through fully mobilize nurses' professional interest and enthusiasm，improve mental resilience to promote the improvement of subjective well-being and maintain the mental health of nurses in operating room.

Key words: Operating room nurse, Mental resilience, Degree of work boredom, Subjective well-being, Mediation effect