Simultaneous determination of multiple biological monitoring indicators in urine by headspace gas chromatography-mass spectrometry

Abstract

Abstract: Objective To establish a headspace gas chromatography-mass spectrometry（GC-MS） method for the determination of biological monitoring indicators in urine,such as acetone,1-bromopropane,dichloromethane,2,5-hexanedione,o-cresol and phenol. Methods The urine sample was sealed after adding anhydrous sodium sulfate,and was determined by GC-MS with headspace injection. Results The linearity of each component in urine determined by this method was good within each concentration range,the correlation coefficients were between 0.999 5 and 0.999 9,the detection limit was 0.4-20.0 μg/L,the sample recovery rate was 84.7%-115.6%,and the relative standard deviations were between 2.6% and 8.9%. Conclusion This method is simple,accurate,and highly sensitive,which is suitable for biological monitoring of occupational exposure to chemical harmful factors,and rapid detection of poisoning emergency samples.

Key words: Headspace, Gas chromatography-mass spectrometry, Urine, Biological monitoring

CLC Number:

R135.1

HE Zong-jian, QIN Li-mei, ZHU Ding-ji, NING Pan-liang. Simultaneous determination of multiple biological monitoring indicators in urine by headspace gas chromatography-mass spectrometry. [J]OCCUPATION AND HEALTH, 2023, 39(4): 467-470.

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