Study on correlation between Helicobacter pylori infection and dyslipidemia in occupational population

Abstract

Abstract: Objective To understand Helicobacter pylori（HP） infection in occupational population,explore the correlation between HP infection and dyslipidemia in occupational population. Methods The basic data and laboratory test results of 1 799 occupational health examinees who participated in HP screening in Wuhan Prevevention and Treatment Center for Occupational Diseases from July 2020 to June 2021 were collected and analyzed comprehensively. 92 patients with HP infection were selected by stratified sampling according to age and sex as group A. Among 1799 occupational health examinees,95 healthy subjects who were not infected with HP were selected as group B. The systolic blood pressure（SBP）,diastolic blood pressure（DBP）,body mass index（BMI）,serum triglycerides（TG）,totalcholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,creatinine（CR）,uric acid（UA）,fasting plasma glucose（FBG）,alanine aminotransferase（ALT）,asparagine aminotransferase（AST）,platelet （PLT） and platelet distribution width （PDW） were statistically analyzed. Results Among the 1 799 occupational health examinees,559 cases were positive for HP infection,with an infection rate of 31.07%. There were no statistically significant differences in the infection rate among different genders and ages（all P>0.05）. Among the 1 799 occupational health examinees,there were 475 cases with dyslipidemia,with a dyslipidemia rate of 26.40%. The dyslipidemia rate of males and females was 28.64% and 21.02% respectively,and the difference was statistically significant（P<0.05）. Among 475 patients with dyslipidemia,the mixed male dyslipidemia rate was 14.29%,and the mixed female dyslipidemia rate was 24.32%. There was a statistically significant difference in the prevalence of mixed dyslipidemia between men and women（P<0.05）. Among 475 patients with dyslipidemia,those with HP infection accounted for 35.78%. The patients with positive HP and mixed dyslipidemia accounted for 9.41% of the total patients of dyslipidemia and positive HP,while the patients with negative HP and mixed dyslipidemia accounted for 20.66% of the total patients of dyslipidemia and negative HP,and the difference was statistically significant（P<0.05）. The levels of BMI,SBP,TG,TC,LDL-C,FBG and UA in group A were higher than those in group B,and the differences were statistically significant（all P<0.05）. The multivariate logistic regression analysis showed that the increase of TC and UA might be the influencing factors of HP infection. Conclusion The prevalence rate of HP infection and dyslipidemia is high in the occupational health examination population,HP infection is closely related to dyslipidemia,therefore,joint prevention and control of related diseases should be improved.

Key words: Occupational population, Helicobacter pylori, Dyslipidemia, Correlation

CLC Number:

R181.3

LI Nian-nian, ZHANG Ping-an. Study on correlation between Helicobacter pylori infection and dyslipidemia in occupational population. [J]OCCUPATION AND HEALTH, 2023, 39(6): 779-783.

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