Effect of tocotrienol on the immune function of mice

Abstract

Abstract: Objective To understand the effects of tocotrienols on immune function in mice. Methods In accordance with the requirements of the "Technical Specifications for the Testing and Evaluation of Health Foods",three dosage groups（50,75,and 100 mg/kg·BW） and one negative control group were established. After 30 days of oral administration of different doses of tocotrienol,changes in the immune organ-to-body weight ratio,cellular immune function,humoral immune function,mononuclear macrophage function,and natural killer（NK） cell activity were compared among the mice. Results Compared with the control group mice（223.0±6.7）,the HC₅₀ values of the 75 and 100 mg/kg·BW dose groups（238.0±7.3,245.2±7.8） were significantly increased,and the differences were statistically significant（all P<0.05）. The number of antibody producing cells in the 75 mg/kg·BW group of mice[（44.4±5.7）×10³] increased compared to the control group[（36.7±6.2）×10³],and the difference was statistically significant（P<0.05）. The transformation ability of splenic lymphocytes induced by conanavalin A（ConA） promoted by tocotrienol in the 75 and 100 mg/kg·BW groups（0.249±0.042,0.256±0.033） was significantly higher than that in the control group（0.183±0.064）,and the differences were statistically significant（all P<0.05）.The difference in left metatarsal thickness between the 100 mg/kg·BW group of mice before and after sheep red blood cell attack[（0.60±0.14） mm] was significantly higher than that of the control group[（0.47±0.08）mm],and the difference was statistically significant（P<0.05）. The NK cell activity of the 75 and 100 mg/kg·BW groups was 24.8±4.8 and 26.4±7.8,respectively,which was significantly higher than that of the control group（14.2±4.3）,and the differences were statistically significant（both P<0.05）. Conclusion Tocotrienol has an enhancing effect on the immune function of mice.

Key words: Tocotrienols, Immune function, Mice

CLC Number:

R114

ZHANG Shujing, ZHOU Qinghong, LIU Yinghua, ZHANG Jing, QIAN Zhiyong. Effect of tocotrienol on the immune function of mice. [J]OCCUPATION AND HEALTH, 2024, 40(11): 1482-1485.

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