Abstract: Objective To analyze the change trend of mortality and premature mortality caused by four major noncommunicable diseases（cardiovascular and cerebrovascular diseases,malignant tumors,chronic respiratory diseases and diabetes,hereinafter referred to as major chronic diseases） in Fengtai District of Beijing from 2014 to 2021,so as to provide data support for chronic disease prevention and control in Fengtai District of Beijing. Methods The crude mortality rate,standardized mortality rate,premature mortality and average years of life lost of registered residents in Fengtai District of Beijing from 2014 to 2021 were calculated,and joinpoint regression model was applied to analyze the time trend by which the average annual percentage change（AAPC） was evaluated. And the average increasing rate of premature mortality was also estimated to verify whether the predicated values meet the standard ones in year 2025 and 2030. Results During 2014-2021,the crude mortality rate of major chronic diseases among 30-69 year-old population in Fengtai District of Beijing was on the rise（AAPC=1.63%,P<0.05）,while the standardized mortality rates in females showed a decreasing trend（AAPC=-3.20%,P<0.05）. The proportion of deaths caused by major chronic diseases to deaths caused by chronic diseases showed upward trend（AAPC=-0.07%,P<0.05）. The proportion of deaths caused by major chronic diseases to total deaths was on the rise（AAPC=1.28,P<0.05）. The proportion of deaths caused by chronic diseases before 70 years old showed a downward trend（AAPC=-0.91,P<0.05）. The premature mortality probability of major chronic diseases reflected in the range of 9.96% to 11.30% among registered residents in Fengtai District of Beijing from 2014 to 2021,and the trend was not statistically significant（AAPC=-0.98%,P>0.05）. The premature mortality probability of major chronic diseases in females showed a decreasing trend（AAPC=-4.97%,P<0.05）. In the same year,the premature mortality probability in males was higher than that in females,and the premature mortality probabilities in malignant tumors and cardiovascular diseases were higher than those in chronic respiratory and diabetes mellitus. The potential years of life lost（PYLL） among 30-69 year-old registered residents in Fengtai District of Beijing from 2014 to 2021 was 379 806.13 person-year. The PYLL of homogeneous chronic diseases in the same year,were higher in men than in women. The average years of life lost（AYLL） among 30-69 year-old registered residents in Fengtai District of Beijing from 2014 to 2021 was 22.47 years. The AYLL of homogeneous chronic diseases in the same year,were higher in men than in women. According to the annual average change rate of premature mortality probability in Fengtai District of Beijing from 2014 to 2021,the predicted value of premature mortality probability in women in 2025 can meet the requirements of the "China's medium and long term plan for the prevention and treatment of chronic diseases（2025）" target value,while the predicted value of premature mortality probability in women in 2030 can meet the requirements of the "healthy China 2030" target value. The predicted value of premature mortality probability for the entire population by 2030 can meet the requirements of the "Healthy Beijing 2030" target value. Conclusion Males are the vital groups in the prevention and treatment of major chronic diseases in Fengtai District of Beijing. It is imperious to improve the monitoring and intervention of related risk factors to reduce the premature mortality probability. Among 30-69 year-old registered residents in Fengtai District of Beijing,the AYLL caused by major chronic diseases in females is higher than that in males,so special attention should be paid to women in the younger age group.

Key words: Major chronic diseases, Premature mortality probability, Years of life lost of premature mortality