Abstract: Objective To investigate the mediating role of nurses' general self-efficacy in their work environment perception and job burnout. Methods In March 2023,a convenience sampling method was used to conduct a questionnaire survey of 1 261 nurses from three grade-A tertiary hospitals in Baoding City using a self-compiled general information questionnaire,nursing work environment scale（C-NWE）,Chinese version of Maslach burnout inventory（MBI）,general self-efficacy scale（GSES）,and the data were analyzed. Results The total scores of C-NWE,MBI,GESE for 1 261 nurses were （123.32±24.14）,（65.80±23.33） and （28.27±6.83）points,respectively. The detection rates of zero,mild,moderate,and severe job burnout were 24.74%,24.66%,47.18% and 3.40%,respectively. General self-efficacy had a partial mediating effect between nursing work environment and job burnout,with an effect value of -0.097,accounting for 21.54% of the total effect. General self-efficacy had a moderating effect on the relationship between nursing work environment and job burnout（β=0.005,△R²=0.003,P<0.05）. Conclusion The current situation of job burnout among nurses in three grade-A tertiary hospitals in Baoding is not optimistic and should be taken seriously by hospital managers. Nurses' general self-efficacy has both mediating and moderating effects between the nursing work environment and job burnout. Nursing managers should carry out targeted interventions from two aspects：the nursing work environment at the organization level and the general self-efficacy at the individual level.

Key words: Work environment perception, Job burnout, General self-efficacy, Mediation effect, Moderation effect.