Abstract: Objective To understand the high-risk behaviors and the infection status of human immunodeficiency virus（HIV）,treponema pallidum（TP） and hepatitis C virus（HCV） among drug users in Zhenjiang City,and to provide basis for the intervention of drug users. Methods s From January 2020 to December 2021,858 people were selected from the managers of compulsory drug treatment centers captured by the Public Security Bureau by stratified sampling,including 805 people who were willing to participate in the survey.After informed consent for testing,demographic and high-risk behavior information was collected,and venous blood was collected for HIV,TP,HCV testing. Results A total of 805 people were surveyed and 785 valid questionnaires were collected,with a response rate of 97.52%.The utilization rates of new drugs and traditional drugs were 82.0%and 18.0%,respectively.The infection rates of HIV,TP and HCV were 2.3%,13.0%and 7.7%,respectively.Multivariate logistic regression analysis showed that students or unemployed（OR=3.836,95%CI：2.044-7.497） and income >6 000 yuan/month（OR=2.856,95%CI：1.316-6.469） were more likely to use new drugs.The infection rate of TP using new drugs was higher（OR=3.477,95%CI：1.239-12.840）,while the infection rates of HIV（OR：0.086,95%CI：0.018-0.357） and HCV（OR：0.082,95%CI：0.035-0.188） among traditional drug users were higher（all P<0.05）. Conclusion In recent years,the use of new drugs among drug users in Zhenjiang City is far more than that of traditional drugs,and the risk of syphilis infection among people who take new drugs such as ecstasy and/or K powder is higher than that of traditional drugs.It is necessary to increase the publicity of the harmfulness of new drugs,and focus on monitoring and comprehensive intervention should be carried out for drug users who are young,have low education and have many sexual partners.

Key words: New drugs, AIDS, Syphilis, Hepatitis C infection rate, Cross sectional study