Research progress on regulation of environmental endocrine disrupting chemicals on the expressions and transactivation of peroxisome proliferator activated receptor γ

Abstract

Abstract: Mounting evidence from experiment and population studies has shown that environmental endocrine chemicals（EDCs） can also affect the normal lipid metabolism of the body,in addition to interfere with the normal function of immune,nervous,reproductive and other systems.The peroxisome proliferator-activated receptor γ（PPARγ） mediated adipose differentiation is a hot topic in EDCs studies.In this review,the structural characteristics,physiological functions of PPARγ,and the regulation of PPARγ expression by EDCs were systemically introduced,intending to provide reference for a comprehensive assessment of the health risks of EDCs.

Key words: Endocrine disruptors chemicals, Nuclear receptor, Lipid metabolism, Obesity

CLC Number:

CAO Yaqiang, MIAO Ke, GAO Xu, YU Jianxia, XU Zining, CHEN Yuanyuan. Research progress on regulation of environmental endocrine disrupting chemicals on the expressions and transactivation of peroxisome proliferator activated receptor γ. [J]OCCUPATION AND HEALTH, 2024, 40(5): 711-715.

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