Research progress on HLA gene polymorphism and immune efficacy and safety of hepatitis B vaccine

Abstract

Abstract: In recent years,the correlation of human leukocyte antigen（HLA） gene in the immune effect of hepatitis B vaccine has been concerned by many medical experts.This article summarizes the related research of HLA gene in the immune effect of hepatitis B vaccine,discusses the relationship between HLA gene polymorphism and immune response and adverse reactions of hepatitis B vaccine,summarizes the related mechanism of different HLA genes on the immune effect of hepatitis B vaccine,and provides a scientific basis for personalized vaccination of hepatitis B vaccine in different HLA populations.This article reviews the general situation of HLA gene,the response effect of HBV vaccine and its related mechanism.

Key words: Human leukocyte antigen, Gene polymorphism, Hepatitis B, Vaccine

CLC Number:

R181.3

WANG Weiping, BAI Yu, FENG Yong, CHENG Wanran, YANG Tian, DENG Pengfei. Research progress on HLA gene polymorphism and immune efficacy and safety of hepatitis B vaccine. [J]OCCUPATION AND HEALTH, 2024, 40(6): 856-859.

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