Abstract: Objective To investigate the situation and influencing factors of Mycobacterium tuberculosis infection in student close contacts with pulmonary TB patients among schools in Pudong New Area of Shanghai from 2019 to 2022,so as to provide reference for subsequent tuberculosis screening and prevention and control strategies in schools with low tuberculosis epidemic areas. Methods The purified protein derivative test（PPD）,interferon-γ release assay（IGRA） and/or X-ray chest radiography and questionnaire were carried out among the student close contacts of school TB patients in Pudong New Area of Shanghai from 2019 to 2022. The influencing factors of Mycobacterium tuberculosis infection among close contacts in schools were analyzed by univariate analysis and logistic regression model. Results After screening 6 422 close contacts of the school,31 confirmed cases of pulmonary tuberculosis were found,accounting for 0.48%,and 485 cases of Mycobacterium tuberculosis infection were found,accounting for 7.55%. Logistic regression showed that the risk factors of tuberculosis infection in student close contacts included central source of students[OR（95%CI）=1.530（1.163-2.013）],western source of students[OR（95%CI）=2.029（1.569-2.623）],universities and technical secondary schools[OR（95%CI）=4.719（1.132-19.670）] and previous exposure to tuberculosis[OR（95%CI）=2.220（1.349-3.652]. The index cases identified by health examination[OR（95%CI）=0.560（0.380-0.824）] was a protective factor for close contacts of tuberculosis in schools. Conclusion It is necessary to strengthen the medical observation of college close contacts. At the same time,the school should focus on the health of students from the high epidemic area,strengthen the school entrance and routine physical examination,in order to early detect the TB cases on campus,and reduce the campus transmission.

Key words: School, Mycobacterium tuberculosis, Close contacts, Influencing factors