Abstract: Objective To establish a liquid-liquid extraction-gas chromatography-mass spectrometry internal standard method for the simultaneous determination of twenty plasticizers in water. Methods Totally 250 mL water samples were extracted directly with 10 mL dichloromethane,concentrated and separated by DB-5MS UI column（30 m×0.250 mm×0.25 μm）,and then analyzed by selective ion monitoring（SIM） mode of gas chromatography-mass spectrometry（GC-MS）. Qualitative analysis was performed by retention time and relative abundance of characteristic ions,and quantitative analysis was performed by the internal standard method. Results Twenty plasticizers were effectively separated and showed good linear relationship（r>0.995） in the range of 0.10-15.00 μg/mL. The detection limits and quantitative limits of the method were 0.004-0.34 μg/L and 0.01-1.15 μg/L. The recoveries and relative standard deviations were 63.7%-109.0% and 0.87%-11.10%. Conclusion The method is simple,sensitive and accurate,and is suitable for simultaneous detection of multiple plasticizers in water. It can provide technical reference for simultaneous detection of multiple plasticizers in water.

Key words: Gas chromatography-mass spectrometry, Liquid-liquid extraction, Plasticizers, Water