Abstract: Objective To understand the effect of humanistic care based on positive psychology on negative emotion,stress response and hope level of patients with Acquired immune deficiency syndrome（AIDS）. Methods 60 AIDS patients admitted to the Changsha First Hospital from September 2023 to March 2024 were selected and divided into a control group and an observation group according to the nursing plan. The control group（30 cases） adopted routine nursing plan,while the observation group（30 cases） adopted humanistic nursing based on positive psychology theory on the basis of routine nursing care. The changes of emotional state,hope level,medication compliance and stress response were compared between the two groups. Results The scores of self-rating anxiety scale（SAS） and self-rating depression scale（SDS） in the observation group after nursing were（31.93±1.23） and（33.03±1.75）points,respectively,which were lower than those of the control group[（40.30±2.52） and （41.63±2.30）points]（both P<0.05）. After nursing,the medication compliance of the observation group was 93.33%,which was higher than 66.67% of the control group（P<0.05）. After nursing,the total score and dimensions scores of herth pope Index（HHI） in the observation group were （32.90±4.40）,（10.77±1.14）,（11.67±1.63）and（10.53±1.68）points,respectively,all higher than those in the control group [（27.43±3.56）,（8.93±1.01）,（10.07±1.39）,and（8.40±1.19）points]（all P<0.05）. After nursing,the total score and various dimensions score（emotional response score,behavioral response score,physical response） of the stress response questionnaire（SQR） in the observation group were（38.20±2.61）,（15.93±1.05）,（8.97±0.76）,（13.30±0.88）points,which were significantly lower than those in the control group[（48.67±4.26）,（20.40±1.69）,（11.07±1.48）,and （17.07±1.17）points]（all P<0.05）. Conclusion The humanistic care based on positive psychology theory for AIDS patients can effectively reduce their negative emotions and stress response,and improve their hope level and degree of cooperation,which has the value of further popularization and application.

Key words: Acquired immune deficiency syndrome（AIDS）, Positive psychology, Humanistic care, Negative emotions