Research progress on detection methods of benzene series and their metabolites in biomaterials

Abstract

Abstract: The detection and analysis of benzene,toluene,ethylbenzene,and xylenes（BTEX） and their metabolites play an important role in acute and chronic benzene poisoning,occupational disease diagnosis and biological monitoring. One of the problems to be solved is to develop techniques for the accurate detection of trace amounts and near-threshold benzene series and their metabolites,and to solve new pretreatment techniques for the detection of complex matrices in biomaterials. At present,the common detection methods at home and abroad include gas chromatography-mass spectrometry,liquid chromatography,liquid chromatography-tandem mass spectrometry,etc. This article mainly reviews the research progress of the common and new pretreatment technologies of these detection methods in blood and urine,such as liquid-liquid extraction,purge and trap method,dynamic headspace needle capture method,electric membrane extraction,headspace solid phase microextraction,FaUMEx extraction,isotope internal standard dilution method,solid phase extraction,and benzene series and their metabolites detection.

Key words: Biomaterials, Benzene series and its metabolites, Detection method, Research progress

CLC Number:

R-115

GAO Jinlong, ZHAO Yi, WANG Yuxia, LI Yongjun, LIU Yakun. Research progress on detection methods of benzene series and their metabolites in biomaterials. [J]OCCUPATION AND HEALTH, 2025, 41(14): 2002-2008.

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