Abstract: Objective To understand the correlation between innovative performance,job prosperity,and work values of nurses in grade-A tertiary hospitals in Tianjin,analyze the mediating effect of job prosperity on innovative performance and work values,and provide reference for constructing intervention plans to improve nurses' innovative performance. Methods From February to May 2024,a convenience sampling method was used to select 511 nurses from grade-A tertiary hospitals in Tianjin. A questionnaire survey was conducted using a general information questionnaire,a work values scale,a job prosperity scale,and an innovation performance scale,and the data were analyzed. Results The total scores for innovative performance,work values,and job prosperity of nurses in grade-A tertiary hospitals in Tianjin were （44.73±10.92）,（86.89±12.45） and （35.89±5.79）points,respectively. The total score of innovation performance was positively correlated with the total scores of work values and job prosperity（r=0.470, 0.663,both P<0.01）. The mediating effect of job prosperity between the two was 0.217,accounting for 55.36% of the total effect（P<0.01）. Conclusion The innovation performance,work values,and job prosperity of nurses in grade-A tertiary hospitals in Tianjin are all at a medium to high level,with some room for improvement,and job prosperity plays a partial mediating role between the two. Managers can stimulate nurses' job prosperity status,establish innovative,progressive,friendly,and diligent work values,and at the same time stimulate innovation enthusiasm in clinical practice,encourage nurses to engage in innovative performance behavior,and promote the high-quality development of clinical nursing.

Key words: Grade-A tertiary hospitals, Nurse, Work values, Job prosperity, Innovation performance, Intermediary effect