Abstract: Objective To analyze the geographical and temporal changes of HIV-1 molecular subtypes in Chinese elderly population,and provide scientific basis for formulating targeted prevention and control measures. Methods Retrieve all relevant research literature published in databases such as Pubmed,ScienceDirect,Web of Science,CNKI,and Wanfang before August 12,2024,and use meta-analysis to estimate the combined proportion of HIV-1 molecular subtypes in the elderly population. Subgroup analysis was arranged by sampling area and time period,publication bias was evaluated by Begger's and Egger's test,and the stability of merger ratio was evaluated by sensitivity analysis. Results A total of 39 articles were included in this study,and CRF01_AE,CRF07_BC and CRF08_BC were the three most widely distributed subtypes in the elderly population in China. The merger ratio of CRF01_AE was 37.5%（95%CI：30.8%-44.1%）,CRF07_BC was 28.3%（95%CI：22.6%-34.1%）,and CRF08_BC was 21.0%（95%CI：17.2%-24.8%）. Subgroup analysis showed that the proportion of CRF01_AE subtype was the highest among the elderly in China in 2016 and before,and the proportion gradually decreased over time. After 2021,the proportion of CRF07_BC and CRF08_BC subtypes were higher than that of CRF01_AE,and the highest was CRF08_BC subtype. The proportion of CRF07_BC subtypes in the eastern part of China was the highest,while the proportion of CRF01_AE in the western and central regions was the highest. Conclusion The molecular subtypes of HIV-1 epidemic strains in the elderly in China are complex and diverse,and the proportion of each subtype changes with time in different regions. It is necessary to further strengthen the molecular epidemiological monitoring of people aged 50 and above to reduce the risk of AIDS transmission.

Key words: HIV-1, Elderly population, Analyze subtypes, Meta-analysis