Abstract: Objective To explore the willingness,influencing factors,and functional demands for the use of AI-Chatbot for vaccination among residents in Tianjin in 2025,and to provide a scientific basis for establishing the Tianjin's public service platform of vaccination. Methods A convenience sampling questionnaire survey was conducted among Tianjin residents in March 2025. A questionnaire survey was administered through the Tianjin vaccination public service platform to analyze the factors influencing their willingness to use the AI-Chatbot for vaccination and their associated functional demand. Results A total of 8 109 participants were included,among whom 7 208(88.89%) were female and 901(11.11%) were male. The number of participants aged 18-<30,30-<40,40-<50,and ≥50 years was 1 585(19.55%),4 267(52.62%),2 131(26.28%),and 126(1.55%),respectively. The overall willingness rate to use the AI-Chatbot for vaccination among the study participants was 72.02%(5 840/8 109). Individuals under the age of 50,with a higher educational attainment and monthly household income per capita,had a higher willingness to use AI Chatbot,additionally,individuals with higher satisfaction levels from previous AI-Chatbot applications and greater awareness of vaccines were more inclined to use it(all P<0.05). 71.53%(5 800/8 109) of respondents supported integrating the AI-Chatbot into Tianjin's public vaccination service platform,with desired functions including personalized vaccination recommendations(78.04%),rapid and accurate vaccine inquiry(76.62%),and intelligent question recommendation(72.95%). Conclusion Tianjin residents demonstrated a high willingness to use an AI-Chatbot for vaccination. When establishing an AI-powered vaccination public service platform,it is essential to fully consider demands in aspects such as information accuracy,reply credibility,and personalized services to ensure that the information provided is precise and reliable.

Key words: Artificial intelligence, Artificial intelligence chatbot, Vaccination, Willingness