Abstract: Objective To understand the current situation of occupational hazards in high-toxicity and high-dust enterprises in Shanghai Chemical Industry Zone,further strengthen the prevention and control of occupational hazards caused by dust and toxins in the chemical industry zone,control and eliminate occupational hazards,and provide data support for occupational health management in the chemical industry zone. Methods From July 2022 to January 2023,a special investigation on occupational hazards of dust toxicity was organized in the Shanghai Chemical Industry Zone. The "Employer Dust,Toxic Occupational Disease Hazard Self-Inspection Form" was used to distribute and collect dust and toxic enterprises in the chemical industry zone. High toxicity and high dust enterprises in the chemical industry zone were selected for dust toxicity hazards status investigation,occupational hazard factor monitoring was carried out based on the production situation of the enterprises,and the data were summarized and statistically analyzed. Results In Shanghai Chemical Industry Zone,there were 29 enterprises with high toxicity and high dust,with medium-sized enterprises（41.38%） and chemical raw materials and chemical products manufacturing industry （79.31%） accounting for the highest proportion. Enterprises in the chemical industry zone were better in occupational disease hazard project declaration,regular occupational disease hazard factor detection and occupational health examinations. However,there were deficiencies in the training of the main person in charge and occupational health management personnel,the rationality of protective measures,and the effectiveness of facilities against dust and poison,mainly concentrated in small and medium-sized enterprises and the manufacturing industry of chemical raw materials and chemical products. The test results of occupational hazard factors showed that the qualification rate of the total point detection of occupational hazard factors was 96.35%,with formaldehyde and dust exceeding the standard.There were 5 enterprises（17.24%） that exceeded the standard,mainly small and medium-sized enterprises and chemical raw materials and chemical products manufacturing. Conclusion By carrying out the investigation on the management of occupational health and protection facilities in high-toxicity and high-dust enterprises,the current situation of occupational health management in high-toxicity and high-dust enterprises in the chemical industry zone has been basically grasped. It is suggested to strengthen the guidance on occupational health technology for small and medium-sized enterprises,attach importance to high toxicity job positions,formulate targeted governance plans,promote the transformation of protective facilities in enterprises,improve the effectiveness of dust and toxic prevention facilities,continuously improve the working environment of workers,and increase the training of occupational disease prevention and control knowledge for main responsible persons and occupational health management personnel,as well as the training of protective skills for on-site operators. Full process supervision should be carried out,and the main responsibility of enterprises should be strictly implemented to ensure the physical and mental health of workers.

Key words: Chemical industry area, Occupational health, Dust toxic control