Analysis of the prevalence and risk factors of cognitive impairment in elderly outpatients aged ≥65 years in Panyu District of Guangzhou City

Abstract

Abstract: Objective To investigate the prevalence rate and potential risk factors of cognitive impairment in elderly patients aged ≥65 years in Panyu district of Guangzhou,and to prevent and delay the transformation of cognitive function from mild cognitive impairment to dementia. Methods The data of patients aged ≥65 years who seek outpatient treatment or undergo health examination in Panyu District Health Management Center,Shilou Community Health Service Center,Donghuan Street Community Health Service Center,Qiaonan Street Community Health Service Center and Shatou Street Community Health Service Center in Guangzhou from January to December 2023 were collected. The mini-mental state examination（MMSE） was used for cognitive assessment,and the prevalence of cognitive impairment was statistically analyzed and multivariate logistic regression analysis was performed. Results Among 10 075 elderly participants,the prevalence of cognitive impairment was 61.2%（6 065 people）. Multivariate logistic analysis identified five interventionable risk factors independently associated with cognitive impairment：stroke（OR=1.363,95%CI：1.160-1.603）,hyperlipidemia（OR=1.785,95%CI：1.681-1.905）,insomnia（OR=2.387,95%CI：2.144-2.659）,mental illness（OR=3.104,95% CI：1.721-5.598） and alcohol consumption（OR=1.333,95%CI：1.074-1.654）. Subgroup analysis revealed that Parkinson's disease was another risk factor for cognitive impairment in older women. Conclusion The prevalence rate of cognitive impairment was higher in elderly outpatients ≥65 years old in Panyu District of Guangzhou. It is important to implement targeted interventions and integrated management strategies to reduce the impact of the five interventionable risk factors in this population.

Key words: Elderly outpatients, Cognitive impairment, Prevalence, Risk factor

CLC Number:

R181.3⁺2

ZHANG Yao, WANG Xiaomei, DAI Jinmei, FU Zhenfa, CHEN Hanwei, HE Bingjie. Analysis of the prevalence and risk factors of cognitive impairment in elderly outpatients aged ≥65 years in Panyu District of Guangzhou City. [J]OCCUPATION AND HEALTH, 2025, 41(2): 206-211.

References

[1] SUH S W,HAN J W,PARK J Y,et al.Impacts of illiteracy on the risk of dementia:A global health perspective[J].J Alzheimers Dis,2016, 53(2):731-741.
[2] XU J,WANG J,WIMO A,et al.The economic burden of dementia in china,1990-2030:Implications for health policy[J].Bull World Health Organ,2017,95(1):18-26.
[3] JIA J,WEI C,CHEN S,et al.The cost of alzheimer's disease in china and re-estimation of costs worldwide[J].Alzheimers Dement,2018,14(4):483-491.
[4] ORNISH D,MADISON C,KIVIPELTO M,et al.Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to alzheimer's disease:A randomized,controlled clinical trial[J].Alzheimers Res Ther,2024,16(1):122.
[5] XUE J,LI J,LIANG J,et al.The prevalence of mild cognitive impairment in china:A systematic review[J].Aging Dis,2018,9(4):706-715.
[6] ORGETA V,QAZI A,SPECTOR A,et al.Psychological treatments for depression and anxiety in dementia and mild cognitive impairment:Systematic review and meta-analysis[J].Br J Psychiatry,2015,207(4):293-298.
[7] OWENS D K,DAVIDSON K W,KRIST A H,et al.Screening for cognitive impairment in older adults:Us preventive services task force recommendation statement[J].JAMA,2020,323(8):757-763.
[8] TANGALOS E G,PETERSEN R C.Mild cognitive impairment in geriatrics[J].Clin Geriatr Med,2018,34(4):563-589.
[9] WINBLAD B,PALMER K,KIVIPELTO M,et al.Mild cognitive impairment--beyond controversies,towards a consensus:Report of the international working group on mild cognitive impairment[J].J Intern Med,2004,256(3):240-246.
[10] FOLSTEIN M F,FOLSTEIN S E,MCHUGH P R."Mini-mental state".A practical method for grading the cognitive state of patients for the clinician[J].J Psychiatr Res,1975,12(3):189-198.
[11] PERNECZKY R,WAGENPFEIL S,KOMOSSA K,et al.Mapping scores onto stages:Mini-mental state examination and clinical dementia rating[J].Am J Geriatr Psychiatry,2006,14(2):139-144.
[12] WARD A,ARRIGHI H M,MICHELS S,et al.Mild cognitive impairment:Disparity of incidence and prevalence estimates[J].Alzheimers Dement,2012,8(1):14-21.
[13] BAI W,CHEN P,CAI H,et al.Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older:A meta-analysis and systematic review of epidemiology studies[J].Age Ageing,2022,51(8):afac173.
[14] JIA L,DU Y,CHU L,et al.Prevalence,risk factors,and management of dementia and mild cognitive impairment in adults aged 60 years or older in china:A cross-sectional study[J].Lancet Public Health,2020, 5(12):e661-e671.
[15] 王艳平,翟静波,朱芳,等.太原市社区老年人轻度认知功能障碍向阿尔茨海默病转归三年随访研究[J].中华流行病学杂志,2011, 32(2):105-109.
[16] MICHIELS L,THIJS L,MERTENS N,et al.In vivo detection of neurofibrillary tangles by(18)f-mk-6240 pet/mr in patients with ischemic stroke[J].Neurology,2023,100(1):e62-e71.
[17] ALLOUBANI A,NIMER R,SAMARA R.Relationship between hyperlipidemia,cardiovascular disease and stroke:A systematic review[J].Curr Cardiol Rev,2021,17(6):e051121189015.
[18] PEARSON O,UGLIK-MARUCHA N,MISKOWIAK K W,et al.The relationship between sleep disturbance and cognitive impairment in mood disorders:A systematic review[J].J Affect Disord,2023,327:207-216.
[19] ZHAO Q,XIANG H,CAI Y,et al.Systematic evaluation of the associations between mental disorders and dementia:An umbrella review of systematic reviews and meta-analyses[J].J Affect Disord,2022,307:301-309.
[20] REHM J,HASAN O S M,BLACK S E,et al.Alcohol use and dementia:A systematic scoping review[J].Alzheimers Res Ther,2019,11(1):1.
[21] CHOLERTON B,JOHNSON C O,FISH B,et al.Sex differences in progression to mild cognitive impairment and dementia in parkinson's disease[J].Parkinsonism Relat Disord,2018,50:29-36.
[22] ROUILLARD M,AUDIFFREN M,ALBINET C,et al.Contribution of four lifelong factors of cognitive reserve on late cognition in normal aging and parkinson's disease[J].J Clin Exp Neuropsychol,2017,39(2):142-162.
[23] SCHRAG M,MUELLER C,ZABEL M,et al.Oxidative stress in blood in alzheimer's disease and mild cognitive impairment:A meta-analysis[J].Neurobiol Dis,2013,59:100-110.
[24] LEE Y G,PARK M,JEONG S H,et al.Effects of baseline serum uric acid and apolipoprotein e4 on longitudinal cognition and cerebral metabolism[J].Neurobiol Aging,2021,106:223-231.