Abstract: Objective To analyze the correlation between CD4⁺ T lymphocytes,viral load and drug resistance detection results of AIDS patients after antiviral therapy in Heze City in 2022,and provide basis for judging the efficacy of anti-viral therapy of AIDS patients. Methods A total of 1 172 peripheral blood samples from AIDS patients in Heze City after antiviral therapy were collected for CD4⁺ T lymphocyte count detection. The plasma was separated and tested for viral load（VL） and drug resistance. The data were analyzed. Results After antiviral therapy,787 patients（67.15%） had CD4⁺ T lymphocytes ≥400 cells/μL and the viral inhibition rate（VL<1 000） reached 92.32%. The composition of CD4⁺ T cell count in AIDS patients with different viral content was negatively correlated（r=-0 250,P<0.01）. The proportion of drug-resistant cases in the failure of antiviral therapy was 44.44%,and the drugs with a higher incidence of resistance were nevirapine（NVP）,efavirenz（EFV）,emtricitabine（FTC） and lamivudine（3TC）. Conclusion In 2022,the proportion of antiviral failure and drug resistance in Heze City is relatively low. The combination of peripheral blood CD4⁺ T lymphocyte detection and viral load detection can better guide the effectiveness of antiviral therapy.

Key words: AIDS patients, CD4⁺ T lymphocyte, Viral load, Drug resistance detection