Status and risk factors of central venous catheter-related thrombosis in cancer patients：A meta-analysis

Abstract

Abstract: Objective To analyze the status and risk factors of central venous catheter-related thrombosis in cancer patients.Methods The related articles on independent risk factors for central venous catheter-related thrombosis in cancer patients were searched in PubMed,Web of Science,Cochrane Library,CNKI,Wanfang,CBM,EBSCO and other databases,which were retrieved from database establishment to May 2022. The outcome measures were combined and meta-analysis was performed using RevMan5.3 software. Results A total of 10 628 patients were included in 17 literatures,including 832 cases of catheter-related thrombosis,the infection rate was 7.82% and there were 10 risk factors. The OR value and 95%CI of independent risk factors were analyzed：age >60 years old（OR=2.73,95%CI：2.62-2.84）,secondary adjustment of catheter position（OR=2.93,95%CI：1.94-4.41）,catheter type（OR=2.08,95%CI：1.58-2.73）,ectopic catheter（OR=2.64,95%CI：2.00-3.48）,D-dimer level（OR=1.18,95%CI：1.10-1.27）,tumor mode metastasis（TNM） was late stage（OR=3.07,95%CI：2.25-4.18）,chemotherapy（OR=2.40,95%CI：1.59-3.62）,tumor site（OR=3.14,95%CI：2.09-4.74）,combined diabetes（OR=2.60,95%CI：1.65-4.09）,previous history of catheter-related thrombosis（OR=4.03,95%CI：1.69-9.61）,and the difference was statistically significant among all groups（P<0.05）. Conclusions Age>60 years old,secondary catheter position adjustment,catheter type,catheter ectopic,higher D-dimer level,advanced TNM stage,chemotherapy,tumor site,previous history of catheter-related thrombosis,and combined diabetes are independent risk factors forcentral venous catheter-related thrombosis in cancer patients. Clinically,attention should be paid to high-risk groups and related risk factors,and effective intervention measures should be taken to reduce the occurrence of central catheter-related thrombosis

Key words: Catheter-related thrombosis, Cancer, Meta analysis, Risk factors

CLC Number:

R181.2

WANG Daoxin, LIU Nan, SHI Zeyuan, PENG Huizhen, GUAN Ningxiao, ZHAO Wenli. Status and risk factors of central venous catheter-related thrombosis in cancer patients：A meta-analysis. [J]OCCUPATION AND HEALTH, 2023, 39(21): 3004-3010.

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