Abstract:

Objective To construct a scientific，standardized and efficient biosafety laboratory filing management system and promote its application，so as to cope with the many challenges existing in the current filing work of China's biosafety laboratories，and to ensure that the laboratories operate in a safe and compliant environment. Methods Using literature analysis，policy analysis，expert interviews and on-site practice，the study designed a standardized filing process and standards，established an expert database according to the selection requirements，developed a filing management platform for biosafety laboratories based on the browser/server architecture，chose the Xinjiang region for practical application，and carried out a full-coverage survey to validate the effectiveness of the system. Results A biosafety laboratory filing management system including filing process，standards，management platform and expert database has been constructed，and full coverage of the application in Xinjiang has been achieved. As of October 2024，Urumqi region has the highest percentage of registered filing units（15.51%），unified filing process and standards，which significantly improved the efficiency and transparency of the filing work，and realized the informatization of the filing work and geographic visualization，and the user satisfaction score reached 4.26 points. The average number of filing of BSL-1 laboratories was 174，and the filing rate has increased from 65.43% to 85.76%，the average number of BSL-2 laboratories filed was 125，and the filing rate has increased from 80.35% to 97.89%，which effectively enhanced the quality of the filing work. The expert pool covered experts in many fields，including laboratory biosafety（67.00%），microbiology（13.00%），environmental science（7.00%），infectious disease（9.00%） and bioinformation and system management（4.00%），and the professionalism and authority of the filing process has been enhanced. Conclusions The construction and application of this system not only effectively dealt with the current difficulties in filing management，but also provided a strong guarantee for the safe operation of biosafety laboratories in China. Through further promotion of this system，the standardization of filing management can be improved nationwide，helping to achieve new heights of development in the management of biosafety laboratories in China.

Key words: Biosafety laboratories, Filing, Management, System building, Application