Investigation on cognition，attitude and willingness toward fecal microbiota transplantation among community residents in Wuhan City

Abstract

Abstract: Objective To understand the cognition and acceptance of fecal microbiota transplantation（FMT），fecal donation intention of community residents in Wuhan City，provide reference for the popularization and application of the technology. Methods In August 2021，totally 582 residents from six major communities in Wuhan were selected as survey subjects by the convenient sampling method，the survey was conducted using self-designed questionnaires，and the results were statistically analyzed. Results The score of cognition o FMT in community residents was （0.26±0.44）points，and the acceptance rate of FMT was 44.16%. There were statistically significant differences in the attitude to FMT treatment among community residents with different gender，educational background and medical history of gastrointestinal diseases（all P<0.05）. The logistic regression analysis showed that women，college degree or above and those who received FMT had higher willingness to donate feces（OR=3.18，2.36，6.58， 95%CI=1.73-5.84，1.35-4.15，3.30-13.13，all P<0.05）. In addition to the doctor's recommendation，taking fecal bacteria into capsules orally was the most accepted transplant route（32.09%）. Residents were most willing to choose relatives as the source of donors（29.03%）. 79.55% of community residents were willing to donate their own feces. There were statistically significant differences in the fecal donation willingness among residents with different gender，education，occupation and FMT acceptance（all P<0.05）. Conclusions Most community residents have a low awareness of FMT，and their acceptance of FMT treatment is at a moderate level. However，the majority of community residents have a high willingness to donate feces. In the future，the promotion of FMT should be strengthened to make more people realize the clinical value of FMT.

Key words: Fecal microbiota transplantation, Cognition, Attitude, Willingness to donate

CLC Number:

R181.3⁺9

CHEN Meng, WANG Nian, MA Hong-mei, FANG Ting, ZHAO Xue-jiao, FENG Hong. Investigation on cognition，attitude and willingness toward fecal microbiota transplantation among community residents in Wuhan City. [J]OCCUPATION AND HEALTH, 2023, 39(2): 216-220.

References

[1] 陈梦,马红梅,曾文莉,等.粪菌移植方法学现状[J].医学综述,2018,24(23):4673-4677.
[2] SURAWICZ C M,BRANDT L J,BINION D G,et al.Guidelines for diagnosis,treatment,and prevention of Clostridium difficile infections[J].Am J Gastroenterol,2013,108(4):478-498,499.
[3] WEINGARDEN A R,VAUGHN B P.Intestinal microbiota,fecal microbiota transplantation,and inflammatory bowel disease[J].Gut Microbes,2017,8(3):238-252.
[4] HOLLERAN G,SCALDAFERRI F,IANIRO G,et al.Fecal microbiota transplantation for the treatment of patients with ulcerative colitis and other gastrointestinal conditions beyond Clostridium difficile infection:an update[J].Drugs Today(Barc),2018,54(2):123-136.
[5] CUI B,FENG Q,WANG H,et al.Fecal microbiota transplantation through mid-gut for refractory Crohn's disease:Aafety,feasibility,and efficacy trial results[J].J Gastroenterol Hepatol,2015,30(1):51-58.
[6] HALKJAER S I,CHRISTENSEN A H,LO B,et al.Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome:Results from a randomised,double-blind placebo-controlled study[J].Gut,2018,67(12):2107-2115.
[7] 刘巧云,张松,曹海超,等.粪菌移植对顽固性功能性便秘患者临床疗效及生活质量的影响[J].中华消化病与影像杂志(电子版),2017,7(1):4-8.
[8] SUN M F,ZHU Y L,ZHOU Z L,et al.Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice:Gut microbiota,glial reaction and TLR4/TNF-alpha signaling pathway[J].Brain Behav Immun,2018,70:48-60.
[9] KIM M S,KIM Y,CHOI H,et al.Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease animal model[J].Gut,2020,69(2):283-294.
[10] DE-GROOT P F,FRISSEN M N,DE-CLERCQ N C,et al.Fecal microbiota transplantation in metabolic syndrome:History,present and future[J].Gut Microbes,2017,8(3):253-267.
[11] AL-BAKRI A G,AKOUR A A,AL-DELAIMY W K.Knowledge,attitudes,ethical and social perspectives towards fecal microbiota transplantation(FMT) among Jordanian healthcare providers[J].BMC Med Ethics,2021,22(1):19.
[12] REN S S,SUN G,YANG Y S,et al.Chinese physicians' perceptions of fecal microbiota transplantation[J].World J Gastroenterol,2016,22(19):4757-4765.
[13] WU X,DAI M,BUCH H,et al.The recognition and attitudes of postgraduate medical students toward fecal microbiota transplantati-on:A questionnaire study[J].Therap Adv Gastroenterol,2019,12:321909288.
[14] 杨琼.鄂西北地区粪菌移植治疗功能性便秘的认知和态度调查[D].十堰:湖北医药学院,2020.
[15] 曹彦,徐昌圆,陈唯,等.广州市大学生对粪菌移植技术的认知、态度及意愿[J].职业与健康,2018,34(3):387-390.
[16] 韩忠政,李佩,陈钟,等.国内不同人群对粪菌移植的态度调查[J].东南国防医药,2017,19(3):225-230.
[17] 魏鸿园,赵雨,胡宇晴,等.粪菌移植的认知、态度和粪便捐献意愿的现况调查[J].现代预防医学,2019,46(22):4141-4144.
[18] MCSWEENEY B,ALLEGRETTI J R,FISCHER M,et al.In search of stool donors:A multicenter study of prior knowledge,perceptions,motivators,and deterrents among potential donors for fecal microbiota transplantation[J].Gut Microbes,2020,11(1):51-62.
[19] HYDE M K,MASSER B M.Determinants of community members' willingness to donate stool for faecal microbiota transplantation[J].PLoS One,2020,15(12):e243751.
[20] BOLTE L A,KLAASSEN M,COLLIJ V,et al.Patient attitudes towards faecal sampling for gut microbiome studies and clinical care reveal positive engagement and room for improvement[J].PLoS One,2021,16(4):e249405.
[21] ORDUNA P,LOPEZ S Y,SCHMULSON M,et al.A survey using the social networks revealed poor knowledge on fecal microbiota transplantation[J].J Neurogastroenterol Motil,2015,21(2):294-295.
[22] DEFILIPP Z,BLOOM P P,TORRES S M,et al.Drug-resistant E.coli bacteremia transmitted by fecal microbiota transplant[J].N Engl J Med,2019,381(21):2043-2050.
[23] ZHANG F,CUI B,HE X,et al.Microbiota transplantation:concept,methodology and strategy for its modernization[J].Protein Cell,2018,9(5):462-473.
[24] WANG S,XU M,WANG W,et al.Systematic review:Adverse events of fecal microbiota transplantation[J].PLoS One,2016,11(8):e161174.
[25] 张发明,张婷.从粪菌移植到菌群移植[J].科学通报,2019,64(3):285-290.
[26] RAMAI D,ZAKHIA K,OFOSU A,et al.Fecal microbiota transplantation:Donor relation,fresh or frozen,delivery methods,cost-effectiveness[J].Ann Gastroenterol,2019,32(1):30-38.