Historical evolution and development status of fecal microbia transplantation

Abstract

Abstract: The fecal microbia transplantation（FMT） is a new technology to treat diseases by reconstructing the intestinal flora of patients. It had developed rapidly in recent years and had shown an important value in the treatment of many diseases. However,the public knows very little about it. We review the historical origin,evolution,and development status of FMT at home and abroad,in order to make more people understand the clinical value of FMT.

Key words: Fecal microbia transplantation, Origin, Evolution

CLC Number:

R181.3⁺2

CHEN Meng, WANG Nian, SHEN Xiang-ying, FANG Ting, FENG Hong, ZHAO Xue-jiao. Historical evolution and development status of fecal microbia transplantation. [J]OCCUPATION AND HEALTH, 2023, 39(4): 557-560.

References

[1] 施慧琳,孙学会,许丽,等.人类微生物组发展态势及建议[J].科技导报,2021,39(14):92-99.
[2] 华佗(东汉).华佗神方,华佗治中箭毒神方(第15卷)[M].重庆:中外出版社,1979:144.
[3] 葛洪(东晋).肘后备急方(第2卷)[M].天津:天津科技出版社,2000:36.
[4] 华佗(东汉).华佗神方,华佗取金汁秘法.(第20卷)[M].重庆:中外出版社,1979:284.
[5] 邓凯莉,周玉平,叶国良.粪菌移植的临床应用之关键技术问题和发展趋势[J].现代实用医学,2021,33(3):284-288.
[6] 张发明.粪菌移植:1 700年的医学史及其临床应用[J].湖北民族学院学报(医学版),2012,29(3):1-4.
[7] 向丽园,张发明.粪菌移植在艰难梭菌感染治疗中的应用[J].临床荟萃,2018,33(5):385-389.
[8] 张发明,龙楚彦,李潘.粪菌移植体系的整体整合医学思考[J].生命科学,2017,29(7):651-659.
[9] ZHANG F M,WANG H G,WANG M,et al.Fecal microbiota transplantation for severe enterocolonic fistulizing Crohn's disease[J].World J Gastroenterol,2013,19(41):7213-7216.
[10] 张发明.粪菌移植体系[J].科技导报,2016,34(20):86-92.
[11] 何植,张发明.中华粪菌库的原则、方案和风险管理[J].胃肠病学,2017,22(4):193-198.
[12] BRANDT L J,ARONIADIS O C,MELLOW M,et al.Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection[J].Am J Gastroenterol,2012,107(7):1079-1087.
[13] BORODY T J,KHORUTS A.Fecal microbiota transplantation and emerging applications[J].Nat Rev Gastroenterol Hepatol,2011,9(2):88-96.
[14] BORODY T J,GEORGE L,ANDREWS P,et al.Bowel-flora alteration:A potential cure for inflammatory bowel disease and irritable bowel syndrome?[J].Med J Aust,1989,150(10):604.
[15] SURAWICZ C M,BRANDT L J,BINION D G,et al.Guidelines for diagnosis,treatment,and prevention of Clostridium difficile infections[J].Am J Gastroenterol,2013,108(4):478-498.
[16] CAMMAROTA G,IANIRO G,TILG H,et al.European consensus conference on faecal microbiota transplantation in clinical practice[J].Gut,2017,66(4):569-580.
[17] KNIG J,SIEBENHAAR A,H GENAUER C,et al.Consensus report:Faecal microbiota transfer-clinical applications and procedures[J].Aliment Pharmacol Ther,2017,45(2):222-239.
[18] ZHANG F,ZHANG T,ZHU H,et al.Evolution of fecal microbiota transplantation in methodology and ethical issues[J].Curr Opin Pharmacol,2019,49:11-16.
[19] RAMAI D,ZAKHIA K,OFOSU A,et al.Fecal microbiota transplantation:donor relation,fresh or frozen,delivery methods,cost-effectiveness[J].Ann Gastroenterol,2019,32(1):30-38.
[20] LONG C,YU Y,CUI B,et al.A novel quick transendoscopic enteral tubing in mid-gut:Technique and training with video[J].BMC Gastroenterol,2018,18(1):37.
[21] PENG Z,XIANG J,HE Z,et al.Colonic transendoscopic enteral tubing:A novel way of transplanting fecal microbiota[J].Endosc Int Open,2016,4(6) :610-613.
[22] KUMAR V,FISCHER M.Expert opinion on fecal microbiota transplantation for the treatment of Clostridioides difficile infection and beyond[J].Expert Opin Biol Ther,2020,20(1):73-81.
[23] MCDONALD L C,GERDING D N,JOHNSON S,et al.Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children:2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)[J].Clin Infect Dis,2018,66(7):987-994.
[24] WEINGARDEN A R,VAUGHN B P.Intestinal microbiota,fecal microbiota transplantation,and inflammatory bowel disease[J].Gut Microbes,2017,8(3):238-252.
[25] HOLLERAN G,SCALDAFERRI F,IANIRO G,et al.Fecal microbiota transplantation for the treatment of patients with ulcerative colitis and other gastrointestinal conditions beyond Clostridium difficile infection:An update[J].Drugs Today (Barc),2018,54(2):123-136.
[26] CUI B,FENG Q,WANG H,et al.Fecal microbiota transplantation through mid-gut for refractory Crohn's disease:Safety,feasibility,and efficacy trial results[J].J Gastroenterol Hepatol,2015,30(1):51-58.
[27] HALKJAER S I,CHRISTENSEN A H,LO B,et al.Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome:Results from a randomised,double-blind placebo-controlled study[J].Gut,2018,67(12):2107-2115.
[28] 刘巧云,张松,曹海超,等.粪菌移植对顽固性功能性便秘患者临床疗效及生活质量的影响[J].中华消化病与影像学杂志(电子版),2017.7(1):4-8.
[29] SUN M F,ZHU Y L,ZHOU Z L,et al.Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice:Gut microbiota,glial reaction and TLR4/TNF-alpha signaling pathway[J].Brain Behav Immun,2018,70:48-60.
[30] KIM M S,KIM Y,CHOI H,et al.Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer's disease ani- mal model[J].Gut,2020,69:283-294.
[31] DE-GROOT P F,FRISSEN M N,DE-CLERCQ N C,et al.Fecal microbiota transplantation in metabolic syndrome:History,present and future[J].Gut Microbes,2017,8(3):253-267.
[32] BOEHME M,GUZZETTA K E,BASTIAANSSEN T F S,et al.Microbiota from young mice counteracts selective age-associated behavioral deficits[J].Nature Aging,2021,1(8) :666-676.
[33] BARCENA C,VALDES-MAS R,MAYORAL P,et al.Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice[J].Nat Med,2019,25(8):1234-1242.
[34] D'AMATO A,Di CESARE M L,LUCARINI E,et al.Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients[J].Microbiome,2020,8(1):1877-2013.
[35] KOOTTE R S,LEVIN E,SALOJARVI J,et al.Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition[J].Cell Metab,2017,26(4):611-619.
[36] DE-CLERCQ N C,VAN DEN ENDE T,PRODAN A,et al.Fecal microbiota transplantation from overweight or obese donors in cachectic patients with advanced gastroesophageal cancer:A randomized,Double-blind,Placebo-Controlled,Phase II Study[J].Clin Cancer Res,2021,27(13):3784-3792.
[37] 朱晓霞,林华,黄志华.粪菌移植的现状及未来[J].中国微生态学杂志,2020.32(11):1362-1365.
[38] DEFILIPP Z,BLOOM P P,TORRES S M,et al.Drug-resistant E.coli bacteremia transmitted by fecal microbiota transplant[J].N Engl J Med,2019,381(21):2043-2050.