细胞外囊泡与疾病关联的研究进展

摘要/Abstract

摘要：

本文全面综合了细胞外囊泡多领域前沿研究，深入剖析细胞外囊泡在代谢性疾病、恶性肿瘤、神经系统疾病、心血管疾病、肥胖、免疫相关疾病及皮肤病等方面的作用机制、诊断价值与治疗潜能，通过广泛且深入地综合多个疾病领域的前沿研究成果，系统而全面地阐述了细胞外囊泡在不同疾病背景下的作用机制、诊断价值及治疗潜能。

关键词: 细胞外囊泡, 运动, 疾病, 健康, 机制, 肿瘤

Abstract:

This paper comprehensively integrated the frontier research in multiple fields of extracellular vesicles，deeply analyzes the mechanism of action，diagnostic value，and therapeutic potential of extracellular vesicles in metabolic diseases，malignant tumors，nervous system diseases，cardiovascular diseases，obesity，immune-related diseases and dermatoses，and systematically comprehensively expounded the mechanism of action，diagnostic value and therapeutic potential of extracellular vesicles in different disease backgrounds by extensively and deeply integrating the frontier research results of several fields.

Key words: Extracellular vesicles, Exercise, Disease, Health, Mechanism, Tumor

中图分类号:

R455

要俪娟, 王印凤, 马震南, 陈乐琴. 细胞外囊泡与疾病关联的研究进展. [J]职业与健康, 2026, 42(15): 2154-2160.

YAO Lijuan, WANG Yinfeng, MA Zhennan, CHEN Leqin. Research progress on the association between extracellular vesicles and diseases. [J]OCCUPATION AND HEALTH, 2026, 42(15): 2154-2160.

图/表 7

图1 EVs发展史注：EVs—细胞外囊泡。

图2 运动诱导的EVs对胰岛素敏感性调控的作用机制

图3 心肌细胞缺血缺氧受损，EVs携带的miR-21、miR-133调节心肌细胞

图4 运动诱导的EVs提高BDNF的表达和释放

图5 EVs与抗炎的关联

图6 EVs中的miR-125b和miR-155以促进肿瘤细胞的转移

图7 EVs的免疫调节功能

参考文献 40

[1]	GURUNATHAN S, KANG M H, JEYARAJ M, et al. Review of the isolation,characterization,biological function,and multifarious therapeutic approaches of exosomes[J]. Cells, 2019, 8(4):1-15.
[2]	杜杰. 有氧运动通过抑制肝脏IKKβ/NF-κB信号通路改善胰岛素抵抗小鼠炎症反应[J]. 中国体育科技, 2017, 53(6):101-107.
[3]	HALLING J F, PILEGAARD H. PGC-1α-mediated regulation of mitochondrial function and physiological implications[J]. Appl Physiol Nutr Metab, 2020, 45(9):927-936.
[4]	YING W, RIOPEL M, BANDYOPADHYAY G, et al. Adipose tissue macrophage-derived exosomal mirnas can modulate in vivo and in vitro insulin sensitivity[J]. Cell, 2017, 171(2):372-384.e12.
[5]	XU F, DOU L, YU D, et al. A novel "endocrine hormone":The diverse role of extracellular vesicles in multiorgan insulin resistance[J]. Int J Med Sci, 2024, 21(11):2081-2093.
[6]	DEIULIIS J, SYED R, DUGGINENI D, et al. Visceral adipose microrna 223 is upregulated in human and murine obesity and modulates the inflammatory phenotype of macrophages[J]. PLoS One, 2016, 11:e0165962.
[7]	KWAN H, CHEN M, XU K, et al. The impact of obesity on adipocyte-derived extracellular vesicles.Cell Mol[J]. Life Sci, 2021, 78:7275-7288.
[8]	YU Y, DU H, WEI S, et al. Adipocyte-derived exosomal mir-27a induces insulin resistance in skeletal muscle through repression of PPARγ[J]. Theranostics, 2018, 8:2171-2188.
[9]	CAO M, ZHAO Y, CHEN T, et al. Adipose mesenchymal stem cell-derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances[J]. Biomaterials, 2022, 288:121739.
[10]	WANG L, ZHANG B, ZHENG W, et al. Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway[J]. Sci Rep, 2017, 7(1):5384.
[11]	WU J, DONG T, CHEN T, et al. Hepatic exosome-derived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte[J]. Metabolism, 2020, 103:154006.
[12]	SU T, XIAO Y, XIAO Y, et al. Bone marrow mesenchymal stem cells-derived exosomal mir-29b-3p regulates aging-associated insulin resistance[J]. ACS Nano, 2019, 13(2):2450-2462.
[13]	邓文艺, 屈顺林. EVs 在肥胖引起的胰岛素抵抗中的作用[J]. 生命的化学, 2019, 39(2):373-381.
[14]	DELIBéGOVIC M, HENNI S, GAGNADOUX F, et al. Metabol Study Group.Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance[J]. Diabetologia, 2025, 68(1):231-242.
[15]	CASTAÑO C, NOVIALS A, PÁRRIZAS M. An overview of inter-tissue and inter-kingdom communication mediated by extracellular vesicles in the regulation of mammalian metabolism[J]. Int J Mol Sci, 2023, 24(3):2071.
[16]	STEVENS M T, SAUNDERS B M. Targets and regulation of microRNA-652-3p in homoeostasis and disease[J]. J Mol Med, 2021, 99(6):755-769.
[17]	FENG J, XING W, XIE L. Regulatory roles of micrornas in diabetes[J]. Int J Mol Sci, 2016, 17(10):1729.
[18]	VECHETTI IJ J R, PECK B D, WEN Y, et al. Mechanical overload-induced muscle-derived extracellular vesicles promote adipose tissue lipolysis[J]. FASEB J, 2021, 35(6):e21644.
[19]	BOSTRÖM P, WU J, JEDRYCHOWSKI M P, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J]. Nature, 2012, 481(7382):463-468.
[20]	BRUEN R, FITZSIMONS S, BELTON O. miR-155 in the Resolution of Atherosclerosis[J]. Front Pharmacol, 2019, 10:463.
[21]	王柯, 吕君君, 刘冬梅, 等. 脂肪组织细胞外基质与胰岛素抵抗[J]. 中国生物化学与分子生物学报, 2017(10):993-998.
[22]	刘瑞, 鲁燕, 贾永平, 等. 运动诱导的心脏保护作用及相关分子机制[J], 中华全科医学, 2023, 21(6):1021-1025.
[23]	熊春伟, 张宪亮. 运动调控PI3K/Akt信号通路改善阿尔茨海默病的研究进展[J]. 中国康复医学杂志, 2021, 36(10):1322-1326.
[24]	刘子铭, 景永帅, 张丹参. 不同状态的小胶质细胞在阿尔茨海默病发病机制中的作用[J]. 中国药理学与毒理学杂志, 2023, 37(7):497-498.
[25]	KLUGE A, BUNK J, SCHAEFFER E, et al. Detection of neuron-derived pathological α-synuclein in blood[J]. Brain, 2022, 145(9):3058-3071.
[26]	孟昱含, 邹明新. 外泌体携带毒性蛋白在神经退行性疾病传播中的作用[J]. 生理科学进展, 2024, 55(2):149-154.
[27]	MALLOCI M, PERDOMO L, VEERASAMY M, et al. Extracellular vesicles:Mechanisms in human health and disease[J]. Antioxid Redox Signal, 2019, 30(6):813-856.
[28]	HYLAND M, MENNAN C, DAVIES R, et al. Extracellular vesicles derived from umbilical cord mesenchymal stromal cells show enhanced anti-inflammatory properties via upregulation of miRNAs after pro-inflammatory priming[J]. Stem Cell Rev Rep, 2023, 19(7):2391-2406.
[29]	SALOMON C, DAS S, ERDBRüGGER U, et al. Extracellular vesicles and their emerging roles as cellular messengers in endocrinology:An endocrine society scientific statement[J]. Endocr Rev, 2022, 43(3):441-468.
[30]	DHONDT B, ROUSSEAU Q, DE WEVER O, et al. Function of extracellular vesicle-associated miRNAs in metastasis[J]. Cell Tissue Res, 2016, 365(3):621-641.
[31]	CAMINO T, LAGO-BAAMEIRO NPARDO M. Extracellular vesicles as carriers of adipokines and their role in obesity[J]. Biomedicines, 2023, 11(2):422.
[32]	BEI Y, XU T, LV D, et al. Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury[J]. Basic Res Cardiol, 2017, 112(4):38.
[33]	MAKHIJANI P, MCGAHA T L. Myeloid responses to extracellular vesicles in health and disease[J]. Front Immunol, 2022, 13:818538.
[34]	赵越, 刘志红. EVs与自身免疫性疾病[J]. 肾脏病与透析肾移植杂志, 2017, 26(6):558-561,539.
[35]	KIM B, SULLIVAN K A, BACKUS C, et al. Cortical neurons develop insulin resistance and blunted Akt signaling:A potential mechanism contributing to enhanced ischemic injury in diabetes[J]. Antioxid Redox Signal, 2011, 14:1829-1839.
[36]	KIM H, LEE J W, HAN G, et al. Extracellular vesicles as potential theranostic platforms for skin diseases and aging[J]. Pharmaceutics, 2021, 13(5):760.
[37]	谢治, 李丽丽. miRNA在银屑病发病机制及治疗作用中的研究进展[J]. 中国临床新医学, 2022, 15(11):1092-1096.
[38]	LI Y, XIAO Q, TANG J, et al. Extracellular vesicles:Emerging therapeutics in cutaneous lesions[J]. Int J Nanomedicine, 2021, 16:6183-6202.
[39]	KEE L T, NG C Y, AL-MASAWA M E, et al. Extracellular vesicles in facial aesthetics:A review[J]. Int J Mol Sci, 2022, 23(12):6742.
[40]	孔翔, 徐开颜, 吴芷菁, 等. 小EVs在皮肤光老化等皮肤疾病中的作用及机制研究进展[J]. 中国细胞生物学学报, 2023, 45(2):334-344.