炭黑颗粒遗传毒性及其机制的研究进展

职业与健康 ›› 2025, Vol. 41 ›› Issue (11): 1563-1568.

炭黑颗粒遗传毒性及其机制的研究进展

程萱¹, 姚艳¹, 王堃¹, 张思羽¹, 张智栋¹, 孟涛^1,2

1.山西大同大学脑科学研究所/分子细胞免疫学大同市重点实验室,山西大同 037009;
2.山西大同大学附属第一医院病理科,山西大同 037006

收稿日期:2024-07-18 修回日期:2024-08-19 发布日期:2025-12-12
通信作者: 孟涛,教授,E-mail：taotao198307@163.com
作者简介:程萱,女,在读本科生。
基金资助:
山西省“四个一批”科技兴医创新计划项目（2021XM17）; 山西省基础研究计划项目（202103021224311）

Research progress on genotoxicity and mechanism of carbon black particles

CHENG Xuan¹, YAO Yan¹, WANG Kun¹, ZHANG Siyu¹, ZHANG Zhidong¹, MENG Tao^1,2

1. Institute of Brain Science/Datong Key Laboratory of Molecular and Cellular Immunology, Shanxi Datong University, Datong, Shanxi 037009, China;
2. Department of Pathology, First Hospital of Shanxi Datong University, Datong, Shanxi 037006, China

Received:2024-07-18 Revised:2024-08-19 Published:2025-12-12
Contact: MENG Tao,Professor,E-mail：taotao198307@163.com

摘要/Abstract

摘要： 炭黑（carbon black,CB）是一种性质稳定的纳米级工业材料,已广泛应用于橡胶、轮胎、塑料、电池、印刷等行业。由于CB颗粒粒径小,可以进入细胞内,通过直接或间接作用对遗传物质造成损伤,目前国际癌症研究机构将其归为人类可疑致癌物。多数体外和体内研究证实CB具有遗传毒性,动物研究中仅有大鼠的CB致癌试验阳性,而CB的人群流行病学致癌证据和遗传损伤机制研究相对有限。在CB毒理学资料基础上,本文主要从CB的特性、毒代动力学、职业暴露、遗传毒性评价、遗传毒作用机制及致癌效应几方面进行系统综述,为CB颗粒的健康风险评估和防控措施的制定提供科学依据。

关键词: 炭黑颗粒, 遗传毒性, 氧化应激, 炎症反应, 细胞周期, 表观遗传

Abstract: Carbon black（CB） is a stable nano-scale industrial material,which has been widely used in rubber,tires,plastics,batteries,printing and other industries. Due to the small size of CB particles,they can enter the cell and cause damage to genetic material through direct or indirect effects. At present,the International Agency for Research on Cancer classifies CB as a suspected human carcinogen. Most in vitro and in vivo studies have confirmed the genotoxicity of CB. In animal studies,only rats have been tested positive for the carcinogenicity of CB,while the population epidemiological carcinogenic evidence and the studies of genetic damage mechanism of CB are relatively limited. Based on the toxicological data of CB,this paper systematically reviews the characteristics,toxicokinetics,occupational exposure,genotoxicity assessment,genotoxic mechanism and carcinogenic effects of CB,so as to provide scientific basis for the health risk assessment and the formulation of prevention and control measures of CB particles.

Key words: Carbon black particles, Genotoxicity, Oxidative stress, Inflammatory response, Cell cycle, Epigenetic inheritance

程萱, 姚艳, 王堃, 张思羽, 张智栋, 孟涛. 炭黑颗粒遗传毒性及其机制的研究进展. [J]职业与健康, 2025, 41(11): 1563-1568.

CHENG Xuan, YAO Yan, WANG Kun, ZHANG Siyu, ZHANG Zhidong, MENG Tao. Research progress on genotoxicity and mechanism of carbon black particles. [J]OCCUPATION AND HEALTH, 2025, 41(11): 1563-1568.

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